Pocket Detection Pouch for Simultaneous CBRNe Analysis
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current molecular detection methods for CBRNe threats require power sources, specialized equipment, and proprietary software, making them impractical for field-forward, austere environments, and lack the capability for simultaneous, rapid identification of multiple threats.
Innovation Solution
A pocket-sized, power-free detection device with multiple compartments and channels that uses paper-based and isothermal DNA amplification assays, allowing for simultaneous detection of multiple CBRNe targets without external power, equipment, or software, leveraging commercial off-the-shelf technologies for rapid, eye-readable results.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If molecular detection methods (PCR, LAMP, RPA) are used for CBRNe threat detection, then detection accuracy and capability are improved, but the device requires power sources, specialized equipment, and proprietary software which increases device complexity and reduces ease of operation in field environments
Solution Approach 1:
The patent extracts the essential detection function from complex molecular methods and implements it through simplified paper-based assays and isothermal amplification that can be performed without specialized equipment, power sources, or proprietary software. The detection capability is maintained while removing the burdensome components of traditional molecular detection systems.
Solution Approach 2:
The patent employs disposable paper-based assay formats and single-use detection cartridges that eliminate the need for expensive, complex equipment. These disposable elements provide sufficient detection accuracy for field use while being simple to deploy and discard, reducing the overall device complexity and operational burden.
2Measurement precision
If molecular detection methods are used, then detection capability is improved, but the requirement for power sources and specialized equipment increases device weight and reduces portability
Solution Approach 1:
The patent replaces complex mechanical and electronic systems (thermos-cycling apparatus, power sources, data visualization tools) with simple chemical and physical processes that occur naturally or with minimal intervention. Paper-based assays and isothermal amplification methods enable detection capability without the weight of traditional molecular detection equipment.
3Measurement precision
If traditional molecular detection platforms are deployed, then detection accuracy is improved, but the need for cold chain logistics and specialized equipment reduces ease of operation in austere environments
Solution Approach 1:
The patent designs detection systems that are self-contained and self-sufficient, requiring no external power sources, cold chain logistics, or specialized equipment. The paper-based assays and isothermal amplification methods perform their detection function autonomously under a wide range of environmental conditions, greatly simplifying operation in austere field environments while maintaining detection accuracy.
4Adaptability or versatility
If multiple CBRNe threats are detected simultaneously, then detection versatility is improved, but the complexity of the detection system increases
Solution Approach 1:
The patent employs a universal paper-based assay platform that can detect multiple CBRNe threats simultaneously using the same basic detection principles and equipment. Different paper-based assays can be deployed on the same platform to detect various chemical, biological, radiological, nuclear, and explosive threats, providing multi-threat capability without proportionally increasing system complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid, accurate, and simultaneous detection of multiple CBRNe threats in less than 20 minutes, reducing the burden on warfighters and first responders with a lightweight, customizable, and cost-effective solution that preserves samples for further testing.
Implementation Method 1
isothermal DNA amplification assays
Implementation Method 2
lateral flow immunoassays (LFIs)
Implementation Method 3
colorimetric presumptive identification
Data Source
AI summary
The pocket detection platform (PDP) detects pathogens, toxins and chemicals of interest simultaneously by way of a multi-channeled, soft see-through plastic pouch design that consists of inner and outer compartments that promote compartmentalization and/or unidirectional sample flow. The platform enables the concurrent running of multiple detection assay techniques such as lateral flow immunoassays (LFI), Isothermal molecular assays (i.e., Recombinase Polymerase Amplification, or RPA) and/or paper-based chemical assays (i.e., M8, pH paper) from a single wet or dry sample with minimal sample processing. The PDP reduces soldier overburden by decreasing size weight, and power (SWaP) as well as training time, electronic burden, while providing a flexible, customizable assay platform that can be rapidly produced, assembled, sustained, and when contaminated, easily to dispose of.