Polarization-rotating tissue contrast in medical optical observation

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Solution Overview

Problem

During neurosurgical interventions, nerve fiber tracts are difficult to differentiate from surrounding tissue, posing a risk of damage during tumor or vessel operations, necessitating improved intra-surgical contrasting methods.

Innovation Solution

A medical optical observation instrument with an illumination system producing adjustable linearly polarized light and a rotatable linear analyzer, combined with image processing to maximize image contrast of nerve fiber tracts by optimizing polarization directions, enabling automated contrasting of polarization-rotating tissue.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional illumination and observation systems are used, then the surgical procedure can be performed, but nerve fiber tracts cannot be differentiated from surrounding tissue

Engineering Contradiction:
Improvedifferentiation capabilityVSAvoidrisk of damage
Core Design Contradiction:
Measurement precisionVSReliability

Solution Approach 1:

The patent applies polarization-based optical contrast enhancement to differentiate nerve fiber tracts from surrounding tissue. By using a rotatable linear analyzer in the observation beam path, the system detects polarization direction changes caused by nerve fibers, creating image contrast that allows clear visual differentiation. This resolves the contradiction by enhancing measurement precision (differentiation capability) without compromising reliability (safety), as the optical method is non-invasive and provides real-time guidance during surgery.

Inventive Principle:
Principle #32Color changes

2Measurement precision

If manual adjustment of polarization components is used, then image contrast can be improved, but the operation becomes complex and time-consuming

Engineering Contradiction:
Improveimage contrastVSAvoidoperation complexity
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The patent implements an automated optimization system where the control unit automatically adjusts the rotatable linear analyzer to maximize image contrast of nerve fiber tracts. The system self-regulates by analyzing the captured images and adjusting the analyzer orientation without requiring manual intervention from the surgeon. This resolves the contradiction by maintaining high measurement precision (image contrast) while eliminating operation complexity, allowing the surgeon to focus on the surgical procedure rather than adjusting optical parameters.

Inventive Principle:
Principle #25Self-service

3Ease of operation

If automated optimization is implemented, then the operation is simplified, but device complexity increases

Engineering Contradiction:
Improveautomation levelVSAvoidsystem complexity
Core Design Contradiction:
Ease of operationVSDevice complexity

Solution Approach 1:

The patent integrates the automated polarization optimization system into the existing surgical microscope framework, where the control unit leverages the camera system and image processing capabilities already present in modern surgical instruments. The rotatable linear analyzer is incorporated into the existing observation beam path without requiring separate dedicated equipment. This resolves the contradiction by achieving high automation level (ease of operation) while minimizing additional device complexity through multi-functional integration of components into the standard surgical microscope system.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution effectively enhances the visibility of nerve fiber tracts by maximizing image contrast, reducing the risk of damage during surgeries by providing clear differentiation from surrounding tissue, and can be applied to other polarization-rotating tissues as well.

Implementation Method 1

at least one illumination apparatus, arranged in the illumination system, comprising a polarization portion, which is suitable for producing illumination light with a linear polarization

Methodology Applied
Scientific EffectPolarization: Polarisation

Implementation Method 2

at least one linear analyzer, arranged in the observation system and rotatable about the optical axis of the observation beam path, for determining the polarization direction of the observation light

Methodology Applied
Scientific EffectPolarization analysis: Polarisation

Implementation Method 3

anisotropic substances of the nerve fibers, such as the myelin components, rotate the polarization direction of polarized light

Methodology Applied
Scientific EffectOptical rotation: Polarisation

Data Source

PatentUS10222597B2Medical optical observation instrument and method for contrasting polarization-rotating tissue
Publication Date: 2019.03.05 CARL ZEISS MEDITEC AG
  • US10222597B2 patent drawing
  • US10222597B2 patent drawing
  • US10222597B2 patent drawing

AI summary

A medical optical observation instrument including an illumination system, which provides an illumination beam path for illuminating an observation object with illumination light, an observation system, which provides an observation beam path for observing the observation object and at least one camera for recording a digital image of the observation object, and a device for contrasting polarization-rotating tissue in the observation object. The device for contrasting polarization-rotating tissue in the observation object includes at least one illumination apparatus, arranged in the illumination system, including a polarization portion, at least one linear analyzer, arranged in the observation system and rotatable about the optical axis of the observation beam path, an image processing apparatus connected to the at least one camera, and an optimization apparatus connected to the image processing apparatus and to the at least one rotatable linear analyzer and the polarization portion.