Absorbable Poloxamer-Dextran Bone Hemostatic Composition
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Solution Overview
Problem
Current surgical methods for controlling osseous hemorrhage and promoting bone healing are inadequate, as existing bone hemostatic agents are non-absorbable, ineffective in adhering to bone, and do not reliably promote osteogenesis, while available bone healing materials lack cohesive properties and biocompatibility.
Innovation Solution
A composition comprising solid poloxamer, high molecular weight dextran, and optionally a fatty acid salt, providing a putty-like consistency that adheres to bone and functions as both a mechanical hemostatic agent and an osteogenic promoter, capable of being absorbed by the body.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If non-absorbable bone wax is used for hemostasis, then bleeding control is effective, but osteogenesis is inhibited and infection risk increases
Solution Approach 1:
The patent changes the fundamental parameter of absorbability from non-absorbable (traditional bone wax) to absorbable (poloxamer-dextran composition). This allows the material to perform hemostasis temporarily then be naturally resorbed, eliminating the permanent foreign body that causes infection and osteogenesis inhibition. The composition maintains hemostatic effectiveness during the needed period while avoiding long-term harmful effects.
Solution Approach 2:
The patent uses a composite material system combining poloxamer (for hemostasis and adhesion) with dextran (for absorbability and biocompatibility). This composite approach allows the material to simultaneously achieve effective hemostasis, bone adhesion, and natural resorption, resolving the contradiction between hemostatic reliability and harm reduction.
2Object-generated harmful factors
If paste-like bone healing materials are used to fill defects, then osteogenesis is promoted, but adhesion to bone is unreliable and hemostasis is ineffective
Solution Approach 1:
The patent creates a multi-functional material that simultaneously performs hemostasis, adhesion to bone, and promotion of osteogenesis. The poloxamer component provides adhesion and hemostasis, while the dextran component supports osteogenesis and ensures absorbability. This universal material eliminates the need for separate hemostatic and osteogenic materials.
Solution Approach 2:
The patent changes the physical state parameter from loose paste to cohesive putty-like consistency. This physical transformation allows the material to adhere reliably to bone surfaces while maintaining the ability to promote osteogenesis and provide effective hemostasis, resolving the reliability issues of paste-like materials.
3Reliability
If electrocautery is used for hemostasis, then bleeding is controlled, but tissue damage occurs and osteogenesis is delayed
Solution Approach 1:
The patent replaces the thermal/mechanical action of electrocautery with a chemical/biological hemostatic mechanism. The poloxamer-dextran composition achieves hemostasis through adhesion to exposed bone and promotion of coagulation, avoiding the thermal damage and tissue necrosis caused by electrocautery, thereby preventing osteogenesis delay.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively controls bleeding, promotes bone growth, and is absorbable, reducing the risk of infection and enhancing bone healing without causing tissue damage or delaying osteogenesis.
Implementation Method 1
providing a putty-like consistency that adheres to bone
Implementation Method 2
capable of being absorbed by the body
Data Source
AI summary
The present invention is direct to a body-absorbable, mechanically hemostatic composition comprising a solid poloxamer having an average molecular weight of about 7,000 g/mol to about 15,000 g/mol, a high molecular weight dextran, optionally a fatty acid salt, and water, and a method for mechanically controlling the bleeding of bone comprising applying an effective amount of the composition to the affected area.