Poloxamer Hydrogel Composition for Injectable Sustained Drug Release
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Solution Overview
Problem
Existing drug delivery systems for pain control, such as catheters and bioabsorbable collagen sponges, face issues with mechanical discomfort, limited application size, and stability at refrigerated conditions, while liposome-based systems require refrigeration and have low stability for sustained drug release.
Innovation Solution
A drug delivery composition comprising an amphiphilic block copolymer of poloxamers and a protein extract (VdECM) containing elastin and collagen, which transitions from a sol to a gel at body temperature, allowing easy administration, sustained drug release, and promoting tissue regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If a catheter with micro-holes is inserted into the body for continuous drug infusion, then sustained pain relief is achieved, but patient comfort deteriorates due to pain and restricted movement
Solution Approach 1:
The hydrogel composition serves itself by utilizing the body's own temperature to trigger phase transition from sol to gel state, creating a self-contained drug delivery system that requires no external power source, pump, or catheter. The system automatically forms a stable gel structure at body temperature to sustain drug release while causing no harm to the patient.
Solution Approach 2:
The patent replaces the mechanical catheter-pump system with a chemical hydrogel system that uses temperature-induced phase transition to achieve sustained drug release. This substitution eliminates mechanical invasiveness while maintaining the duration of action, resolving the contradiction between sustained relief and patient comfort.
2Ease of manufacture
If a bioabsorbable collagen sponge is used for local anesthetic delivery, then no removal procedure is needed, but application flexibility deteriorates due to fixed size and shape requirements
Solution Approach 1:
The hydrogel composition transitions from a dynamic sol state (liquid-like, easy to inject) at room temperature to a gel state (stable, sustained release) at body temperature. This dynamic phase transition provides both ease of administration and adaptability to various application sites, overcoming the limitations of fixed-shaped collagen sponges.
Solution Approach 2:
The patent utilizes temperature as a controlling parameter to change the physical state of the hydrogel from sol to gel. This parameter change enables the system to be easily injected in liquid form and then stabilize in gel form at the application site, providing flexibility in application while maintaining sustained drug release.
3Duration of action of moving object
If liposome-based drug delivery system is used, then sustained drug release is achieved, but storage stability deteriorates due to requirement for refrigeration
Solution Approach 1:
The patent changes the temperature parameter from refrigerated conditions (2-8°C) to body temperature (37°C), triggering the phase transition of the hydrogel from sol to gel state. This parameter change enables sustained drug release without requiring refrigeration, resolving the contradiction between duration of release and storage stability.
Solution Approach 2:
The hydrogel composition undergoes a phase transition from sol to gel state at body temperature, creating a stable structure that sustains drug release over extended periods. This phase transition mechanism provides both sustained action and storage stability, eliminating the need for refrigeration while maintaining long-term drug release capability.
4Duration of action of moving object
If liposome-based system is used, then sustained drug release is achieved, but in vivo stability deteriorates due to low stability of liposomes
Solution Approach 1:
The patent uses a composite hydrogel system combining poloxamer (amphiphilic block copolymer) with gelatin or other biocompatible polymers to create a more stable and reliable drug delivery matrix. This composite structure provides enhanced in vivo stability compared to liposome-based systems while maintaining sustained drug release capability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides stable, sustained drug release for up to 7 days, promotes tissue regeneration, and is biodegradable without requiring removal, suitable for various drugs and application sites, with improved in vivo stability and adhesion.
Implementation Method 1
the amphiphilic block copolymer is in a sol phase at room temperature and undergoes a phase transition to a gel phase at body temperature
Data Source
AI summary
The present invention relates to a hydrogel-based drug delivery system that can efficiently deliver the required amount of a drug to a desired location for a longer period of time. The hydrogel-based drug delivery system includes: an amphipathic block copolymer including a mixture of a first poloxamer and a second poloxamer that have different molecular weights; and a protein extract (containing elastin and collagen. A drug delivery composition for promoting tissue regeneration, according to the present invention, is mixed with a drug and introduced into the body, thus increasing the excretion time of the drug in the body, has phase transition properties of a liquid (sol) state at room temperature while being gelled at body temperature, thus being convenient to inject as an injectable agent, can be applied to various body parts.