Poly-N-acetylglucosamine Nanofibers for Hemostasis and Wound Healing
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Solution Overview
Problem
Current negative pressure wound therapy devices, such as the VAC system, are limited by their inability to effectively manage bleeding in wounds, especially in patients on anticoagulants, and existing hemostatic agents can induce foreign body responses or have negative effects on wound healing.
Innovation Solution
A system incorporating a semipermeable seal and a hemostatic appliance with poly-N-acetylglucosamine nanofibers attached to a support, such as a foam or screen, that delivers sub-atmospheric pressure for wound healing and hemostasis, promoting uniform pressure distribution and minimizing foreign body responses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing hemostatic agents are applied to wounds, then hemostasis is achieved, but foreign body responses or negative effects on wound healing occur
Solution Approach 1:
The patent changes the chemical composition parameters of hemostatic agents by using poly-N-acetylglucosamine with specific molecular weights (10,000-1,000,000 Daltons) and controlled acetylation degrees (60-100%). These parameter changes transform the material properties to achieve hemostasis while reducing foreign body responses and improving wound healing outcomes.
Solution Approach 2:
The patent creates composite hemostatic materials by combining poly-N-acetylglucosamine with other biocompatible substances such as gelatin, collagen, or chitosan. These composite structures integrate the hemostatic functionality of poly-N-acetylglucosamine with the wound-healing properties of complementary materials, achieving both effective clotting and enhanced tissue regeneration without significant foreign body responses.
2Productivity
If negative pressure is applied to wounds using conventional systems, then wound healing is promoted, but bleeding cannot be effectively controlled
Solution Approach 1:
The patent merges negative pressure wound therapy with hemostatic functionality by integrating poly-N-acetylglucosamine-coated foams or dressings into the VAC system. This combination allows the system to simultaneously achieve effective bleeding control through the hemostatic agent and accelerated wound healing through negative pressure, resolving the limitation of conventional systems that could not effectively manage both functions.
3Stability of the object's composition
If anticoagulants are used in patients, then clotting parameters remain normal, but wound bleeding increases significantly
Solution Approach 1:
The patent uses poly-N-acetylglucosamine as an intermediary substance that facilitates hemostasis at the wound site without interfering with the patient's systemic anticoagulant therapy. The material acts as a local mediator that promotes platelet aggregation and clot formation directly at the wound interface, overcoming the bleeding tendency caused by anticoagulants while preserving normal systemic clotting parameters.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system achieves effective hemostasis and enhances wound healing by accelerating clotting and granulation tissue formation without significant foreign body responses, as demonstrated by increased granulation tissue area and thickness in diabetic mouse models and clinical applications.
Implementation Method 1
The hemostatic agent is composed of poly-N-acetylglucosamine... accelerates clotting
Implementation Method 2
draining fluids from the wound through a tube... Negative pressure is applied to the wound through the tube
Data Source
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AI summary
This invention relates in general to a method and device for facilitating hemostasis and wound healing. In particular, the invention relates to the device comprising a polymeric material disposed on a scaffold that facilitates hemostasis and wound healing. Specifically, the invention contemplates the use of such scaffolds in conjunction with a negative pressure device.