Polyanionic Cyclodextrin Complexes for Renal Protection
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Nephrotoxic drugs cause renal damage through various mechanisms, leading to acute oliguric renal failure, and existing solutions do not adequately address the extent of renal toxicity associated with these drugs.
Innovation Solution
Compositions comprising an anionically substituted oligosaccharide, such as a polyanionic cyclodextrin derivative, are used in conjunction with nephrotoxic drugs to inhibit their nephrotoxic effects, reducing renal damage by forming complexes that minimize toxicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If nephrotoxic drugs are administered at high doses to achieve maximum therapeutic efficiency, then the therapeutic effect is improved, but renal toxicity is significantly worsened
Solution Approach 1:
The patent uses cyclodextrin derivatives as intermediary substances that form inclusion complexes with nephrotoxic drugs. The cyclodextrin molecule acts as a mediator, with its hydrophobic cavity encapsulating the drug molecule, thereby modifying the drug's interaction with renal tissues and reducing nephrotoxicity while preserving therapeutic efficacy.
Solution Approach 2:
The patent modifies the chemical parameters of the drug delivery system by using cyclodextrin derivatives with different substitution patterns (e.g., sulfobutyl ether, carboxymethyl groups). These parameter changes in the cyclodextrin structure affect the complexation efficiency and nephroprotective properties, allowing optimization of the therapeutic window.
2Object-affected harmful factors
If conventional nephroprotection methods are used, then some renal protection is achieved, but the extent of nephrotoxicity reduction is insufficient
Solution Approach 1:
The patent employs composite material systems consisting of cyclodextrin derivatives combined with specific counterions (e.g., sodium, potassium) and co-solvents. This composite approach creates a synergistic effect that enhances nephroprotection beyond what single substances can achieve, providing more reliable renal protection.
Solution Approach 2:
The cyclodextrin derivative molecules exhibit local quality differentiation with hydrophilic outer surfaces and hydrophobic inner cavities. This local quality allows selective interaction: the hydrophobic cavity binds the drug while the hydrophilic exterior maintains solubility and reduces renal tubular accumulation, achieving superior nephroprotection.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of polyanionic oligosaccharides significantly reduces renal pathology scores and nephrotoxicity in animal models, demonstrating a protective effect against drugs like methotrexate, doxorubicin, and cisplatin, indicating a substantial inhibition of renal damage.
Implementation Method 1
Compositions comprising an anionically substituted oligosaccharide, such as a polyanionic cyclodextrin derivative, are used in conjunction with nephrotoxic drugs to inhibit their nephrotoxic effects, reducing renal damage by forming complexes that minimize toxicity.
Data Source
Figure 1
Figure 2
Figure 3
AI summary
The present invention provides compositions and methods to reduce renal damage caused by nephrotoxic drugs. The invention provides compositions comprising an anionically substituted oligosaccharide, a nephrotoxic drug and a pharmaceutically acceptable carrier, where the oligosaccharide is present in an amount effective for substantially inhibiting the nephrotoxic effect of the drug.