Polycarbonate Resin Composition for Fluorescence Substrates
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Solution Overview
Problem
Aromatic polycarbonate resin is not suitable for fluorescence detection and analysis substrates due to high autofluorescence, despite its heat-resistant and transparent properties, and existing methods to reduce autofluorescence are ineffective.
Innovation Solution
A polycarbonate resin composition with reduced branch structures, achieved by removing micrograins from flakes synthesized via interfacial polymerization, and processed using specific conditions such as injection molding with controlled oxygen concentration and additives, to minimize autofluorescence in the visible light region.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Temperature
If aromatic polycarbonate resin is used for fluorescence detection substrate, then heat resistance and transparency are improved, but autofluorescence increases causing high background noise
Solution Approach 1:
The patent changes the molecular structure parameters of polycarbonate resin by replacing aromatic rings with alicyclic structures, specifically using compounds with formulas (1) and (2) that contain alicyclic groups instead of aromatic groups, thereby reducing autofluorescence while maintaining heat resistance and transparency
Solution Approach 2:
The patent creates a composite resin composition by combining multiple components including polycarbonate resin, alicyclic dicarboxylic acid components, and alicyclic diol components, achieving low autofluorescence properties while maintaining mechanical strength and heat resistance through the synergistic effect of these components
2Object-generated harmful factors
If glass is used as substrate material, then autofluorescence is reduced, but processability and production cost worsen
Solution Approach 1:
The patent employs plastic resin materials that can be easily processed and disposed of, replacing expensive and difficult-to-process glass substrates, while achieving comparable or superior performance in terms of autofluorescence reduction and overall manufacturability
Solution Approach 2:
The patent changes the material parameter from inorganic glass to organic resin, enabling improved processability through standard plastic processing techniques while maintaining low autofluorescence properties through specific molecular structure design
3Illumination intensity
If aromatic polycarbonate resin is used for substrate, then transparency is improved, but detection precision deteriorates due to high background
Solution Approach 1:
The patent changes the chemical structure parameters by eliminating aromatic rings and introducing alicyclic groups, thereby shifting the fluorescence emission spectrum away from the visible detection range while maintaining high transparency in the visible region, thus improving detection precision without sacrificing transparency
Solution Approach 2:
The patent modifies specific local molecular structures (introducing alicyclic groups at specific positions in the polymer chain) to reduce autofluorescence in the detection wavelength range while preserving transparency and other bulk properties where aromatic structures would be beneficial
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution significantly decreases autofluorescence, making the aromatic polycarbonate resin suitable for fluorescence detection and analysis substrates with low background noise, high heat resistance, and transparency, applicable in biochemistry and medical diagnostics.
Implementation Method 1
an aromatic polycarbonate resin has an aromatic ring, and therefore, has a characteristic of having higher potential autofluorescence than other transparent resins
Data Source
AI summary
An aromatic polycarbonate resin composition for a fluorescence detection and analysis substrate by which autofluorescence of an aromatic polycarbonate resin, which has been avoided as a resin for a fluorescence detection and analysis substrate due to a critical defect thereof of having fluorescence in a visible light wavelength region, is significantly decreased, and is highly heat-resistant and highly transparent; and a fluorescence detection and analysis substrate produced by melt molding performed on the aromatic polycarbonate resin composition. A polycarbonate resin composition, including a polycarbonate resin synthesized by an interfacial polymerization method, wherein the polycarbonate resin composition fulfills formula (1) below with respect to fluorescence emission of the composition when being excited by light having a wavelength of 290 nm,|{F(310)−F(450)}/{F(400)−F(450)}|≧40 formula (1)where F(310), F(400) and F(410) are respectively fluorescence emission intensities at wavelengths of 310 nm, 400 nm and 450 nm.