Conjugated Fused Polycyclic Quencher Dissipates Excited State Energy
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing technologies fail to effectively resolve excited state energy in molecules, leading to detrimental reactions such as the formation of reactive oxygen species, which can cause damage to substances and organisms.
Innovation Solution
Conjugated fused polycyclic molecules, particularly those with electron-withdrawing groups, are used to quench and dissipate excited state energy by accepting electrons from chromophores, preventing the generation of reactive oxygen species and returning the molecules to their ground state.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Use of energy by moving object
If a molecule absorbs light energy, then the molecule transitions to an excited state, but this excited state can lead to detrimental reactions such as formation of reactive oxygen species
Solution Approach 1:
The patent introduces a quencher molecule as an intermediary substance that mediates between the excited chromophore and oxygen. The quencher accepts energy from the excited chromophore through collisional energy transfer, preventing direct interaction between the excited chromophore and oxygen that would otherwise generate reactive oxygen species. This intermediary mechanism resolves the contradiction by providing a safe energy dissipation pathway.
Solution Approach 2:
The patent converts the harmful excited state energy that would lead to reactive oxygen species formation into a beneficial process by having the quencher molecule accept this energy and dissipate it harmlessly. The excited state energy, which is initially harmful, is transformed into thermal energy or other non-reactive forms through the quencher, thereby converting a harmful factor into a benign outcome.
2Loss of energy
If existing technologies are used to resolve excited state energy, then some energy dissipation occurs, but the resolution is ineffective and detrimental reactions still occur
Solution Approach 1:
The patent optimizes key parameters of the quencher molecule including its energy levels, molecular structure, and concentration to maximize energy transfer efficiency. By carefully selecting the quencher's triplet state energy to be slightly lower than the chromophore's excited state energy, and by optimizing the quencher concentration, the system achieves reliable and effective excited state resolution that prevents detrimental reactions.
Solution Approach 2:
The quencher molecule serves as an effective intermediary that reliably transfers energy from excited chromophores. This intermediary mechanism ensures consistent and reliable energy dissipation, improving upon existing technologies that fail to effectively resolve excited states. The quencher's specific molecular properties enable reliable energy acceptance and dissipation, preventing reactive oxygen species formation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively prevents the formation of reactive oxygen species, reducing damage to molecules and organisms by efficiently resolving excited state energy, thereby protecting against oxidative stress and photodegradation.
Implementation Method 1
a tricyclic compound may quench singlet and/or triplet excited states of a chromophore by accepting an electron from the chromophore, thereby returning the chromophore back to the ground state
Implementation Method 2
the present disclosure relates to molecules, including conjugated fused polycyclic molecules, that may quench, dissipate, and/or otherwise resolve excited state energy, normally by way of releasing it as heat
Data Source
AI summary
The present disclosure relates, according to some embodiments, to molecules, including conjugated fused polycyclic molecules, that may receive excited state energy from other molecules (e.g., light-absorbing molecules) or directly from the irradiation sources. According to some embodiments, the disclosure relates to molecules, including conjugated fused polycyclic molecules, that may resolve (e.g., quench, dissipate) excited state energy, normally by way of releasing it as heat. (e.g., as heat). Conjugated fused polycyclic molecules of various structures are disclosed including Formula III:The disclosure further relates to methods of use and/or therapy using molecules of Formulas I, II, and/or III.