Polydioxanone Membrane Structure for Guided Tissue Regeneration

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Solution Overview

Problem

Existing dental and medical devices for guided tissue regeneration, particularly for bone defects and connective tissues like gingiva, skin, cartilage, and cornea, lack a solution that combines economic advantages, safety, and reliability, while also mimicking the extracellular matrix and providing mechanical and biological barriers.

Innovation Solution

A dental/medical device comprising an absorbable synthetic membrane made of poly(dioxanone) with optional graphene, designed to mimic the extracellular matrix, offering a mechanical and biological barrier with sub and micrometric fibers, available in various dimensions and supplied sterile, which is gradually absorbed by the body and replaced by new tissue.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If polydioxanone (PDS) membranes are used for guided tissue regeneration, then bone density gain and regeneration results are improved, but postoperative membrane exposures and device exposure rate increase

Engineering Contradiction:

Improvebone density gainVSAvoidmembrane exposure duration

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent modifies the chemical composition parameters of the polydioxanone membrane by incorporating specific additives and controlling molecular weight distribution to enhance membrane stability and reduce exposure rate while maintaining bone regeneration efficacy

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite membrane structure combining polydioxanone with other biocompatible materials to improve mechanical strength and stability, reducing the likelihood of postoperative exposure while maintaining the desired bone density gain

Inventive Principle:

Principle #40Composite materials

2Reliability

If absorbable synthetic membranes are used for tissue regeneration, then biological compatibility and gradual absorption are improved, but mechanical strength during the absorption period decreases

Engineering Contradiction:

Improvebiological compatibilityVSAvoidmechanical strength

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

The patent applies local quality enhancement by creating zones of different material properties within the membrane structure, with higher strength regions providing mechanical support while other regions facilitate absorption and tissue ingrowth

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The patent performs preliminary reinforcement of the membrane structure through cross-linking or coating processes before implantation, ensuring adequate mechanical strength is maintained during the critical early absorption phase

Inventive Principle:

Principle #10Preliminary action

3Reliability

If sub and micrometric fibers are used to mimic extracellular matrix, then cell adhesion and tissue regeneration are improved, but manufacturing complexity increases

Engineering Contradiction:

Improvecell adhesionVSAvoidmanufacturing complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent replaces complex mechanical fiber assembly processes with electrospinning or phase separation techniques that automatically generate the required sub and micrometric fiber structures through controlled material deposition

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent controls fiber diameter and porosity parameters during manufacturing to achieve the desired extracellular matrix mimicry while optimizing the manufacturing process for scalability and reduced complexity

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device provides effective guided tissue regeneration with controlled resorption, mechanical strength, and biological compatibility, reducing risks of cross-contamination and immunoreactivity, and supports bone and soft tissue reconstruction with high absorption of fluids and molecules.

Implementation Method 1

absorbable synthetic membrane made of poly(dioxanone)

Methodology Applied

Scientific EffectHydrolysis: Hydrolysis

Implementation Method 2

gradually absorbed by the body and replaced by new tissue

Methodology Applied

Scientific EffectBiodegradation: Decomposition (biological)

Implementation Method 3

The membrane inhibits the migration of undesirable cells in tissue regeneration

Methodology Applied

Scientific EffectPhysical barrier: Physical Containment

Implementation Method 4

high absorption of fluids and molecules

Methodology Applied

Scientific EffectCapillary action: Capillary Action

Implementation Method 5

high absorption of fluids and molecules

Methodology Applied

Scientific EffectAdsorption: Adsorption

Data Source

PatentUS20260000490A1Dental/medical device including polydioxanone, use of such device for guided tissue reconstruction and/or regeneration and production process of such device

Publication Date: 2026.01.01 M3 HEALTH IND E COMERCIO DE PROD MEDICOS ODONTOLOGICOS E CORRELATOS SA

AI summary

The present invention relates to a dental/medical device consisting of an absorbable synthetic membrane, preferably white to gray in color, comprising poly(dioxanone) and optionally graphene and stem cells, to be used in guided tissue reconstruction and/or regeneration of bone defects and other connective tissues (gum, skin, cartilage or cornea, for example). Furthermore, the present invention relates to the use of said device for the above-related applications and to the process of preparing said device.