Polyethyleneimine Gas Sensor for Non-Invasive COPD Diagnosis
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Solution Overview
Problem
Current methods for diagnosing chronic obstructive pulmonary disease (COPD) are invasive, painful, and costly, often requiring healthcare professional intervention, which can cause discomfort and high diagnosis costs.
Innovation Solution
A gas sensing device comprising a substrate with conductive electrodes and a sensing layer made of polyethyleneimine and polyethylene glycol, which absorbs carbon dioxide, connected to a detecting system that measures electrical property changes to determine CO2 concentration non-invasively.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If invasive procedures such as radial artery puncture or endotracheal intubation are used to diagnose COPD, then measurement precision of carbon dioxide concentration is improved, but patient comfort deteriorates and diagnosis cost increases
Solution Approach 1:
The patent introduces a gas sensing device as an intermediary tool that indirectly measures carbon dioxide concentration in exhaled breath, avoiding direct invasive contact with blood vessels or airways while maintaining detection accuracy through electrochemical sensing mechanisms
Solution Approach 2:
The patent replaces mechanical invasive procedures (artery puncture, intubation) with an electrochemical sensing system that detects carbon dioxide through electrical property changes in a sensing layer, eliminating physical trauma while preserving measurement capability
2Measurement precision
If invasive procedures requiring healthcare professional intervention are used, then measurement precision is improved, but device complexity and operation difficulty increase
Solution Approach 1:
The sensing layer autonomously detects carbon dioxide concentration through spontaneous electrochemical reactions, generating electrical signals that directly indicate CO2 levels without requiring complex processing systems or professional operator intervention
Solution Approach 2:
The patent utilizes changes in electrical properties (conductivity, resistance) of the sensing layer as carbon dioxide concentration varies, converting chemical information into easily measurable electrical parameters that simplify the detection system
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device provides a non-invasive, cost-effective means to detect carbon dioxide levels in exhaled breath, enhancing sensitivity and allowing for easy, patient-independent detection of COPD without the need for invasive procedures.
Implementation Method 1
The sensing layer includes polyethyleneimine and polyethylene glycol, and is adapted to absorb carbon dioxide
Implementation Method 2
Electrical property of the gas sensing device changes when the gas sensing device absorbs carbon dioxide
Data Source
AI summary
A gas sensing device includes a substrate, a conductive unit, and a sensing layer. The conductive unit is disposed on the substrate, and includes two electrodes. The sensing layer is disposed on the conductive unit, and is electrically connected with the electrodes. The sensing layer adapted to absorb carbon dioxide includes polyethyleneimine and polyethylene glycol. A detecting system including a testing device, an analyzing device and the aforementioned gas sensing device is also disclosed. The gas sensing device is detachably mounted to and is electrically connected to the testing device. Electrical property of the gas sensing device 100 changes when the gas sensing device 100 absorbs carbon dioxide.