Hyperbranched Polyglycerol Ether Crosslinker for Polysaccharide Hydrogels
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current crosslinking agents for polysaccharides, such as hyaluronic acid, face challenges with toxicity, mechanical instability, and rapid degradation, leading to limited longevity and safety concerns in applications like dermal fillers and therapeutic uses.
Innovation Solution
The development of hyperbranched polyglycerol polyglycidyl ether with a molecular weight of 750 to 15,000 Da and epoxy equivalent weight from 183 to 7,500 g/eq, which acts as a crosslinking agent to create a polysaccharide hydrogel with low crosslinking degree, enhancing mechanical properties and biocompatibility while reducing enzymatic and oxidative degradation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional crosslinking agents are used for polysaccharides, then crosslinking efficiency is improved, but toxicity increases and biocompatibility deteriorates
Solution Approach 1:
The patent changes the chemical parameters of the crosslinking agent by using hyperbranched polyglycerol polyglycidyl ether with controlled molecular weight (750-15,000 Da) and epoxy equivalent weight (183-7,500 g/eq). This parameter optimization enables effective crosslinking while maintaining biocompatibility and reducing toxicity compared to conventional crosslinking agents
Solution Approach 2:
The invention creates a composite crosslinking system combining hyperbranched polyglycerol polyglycidyl ether with polysaccharides to form a hydrogel network. This composite approach leverages the biocompatibility of polyglycerol and the functional properties of polysaccharides, achieving both effective crosslinking and reduced toxicity
2Strength
If high crosslinking degree is achieved, then mechanical stability is improved, but degradation resistance decreases due to rapid enzymatic and oxidative degradation
Solution Approach 1:
The patent optimizes the crosslinking degree parameter to a specific range that balances mechanical stability and degradation resistance. By controlling the epoxy equivalent weight and molecular weight of the crosslinking agent, the invention achieves adequate mechanical strength while maintaining resistance to enzymatic and oxidative degradation
Solution Approach 2:
The hyperbranched structure of the crosslinking agent provides local density variation in the hydrogel network, creating regions of different crosslinking density. This local quality variation allows the material to maintain mechanical stability in load-bearing regions while preserving degradation resistance in other areas
3Reliability
If molecular weight of crosslinking agent is increased, then crosslinking efficiency is improved, but viscosity increases making handling difficult
Solution Approach 1:
The patent identifies and optimizes the molecular weight parameter of the crosslinking agent within the range of 750-15,000 Da. This parameter optimization ensures sufficient crosslinking efficiency while maintaining low enough viscosity for easy handling and processing
Solution Approach 2:
The hyperbranched structure of the crosslinking agent provides dynamic conformational flexibility, allowing the molecule to adapt its shape during crosslinking reactions. This dynamic behavior enables effective crosslinking at lower concentrations, thereby maintaining low viscosity and improved handling ease
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hyperbranched polyglycerol polyglycidyl ether effectively creates a stable, biocompatible crosslinked polysaccharide hydrogel with improved mechanical properties and prolonged degradation resistance, facilitating safe and effective in vivo applications with reduced pain and toxicity.
Implementation Method 1
hyperbranched polyglycerol polyglycidyl ether...acts as a crosslinking agent to create a polysaccharide hydrogel
Data Source
AI summary
The present invention relates to a hyperbranched polyglycerol polyglycidyl ether having a molecular weight from 750 to 15.000 Da; and an epoxy equivalent weight from 183 to 7.000 g/eq. It also relates to a crosslinked polysaccharide obtainable by crosslinking the polysaccharide with the hyperbranched polyglycerol polyglycidyl ether. The present invention also relates to processes for their preparation and their uses in therapy, cosmetic, agriculture and food field.