Biobased Polyglyceryl Esters for Clear Oral Rinses
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Solution Overview
Problem
Existing oral rinse formulations face challenges in achieving clarity, preserving antimicrobial activity, and sustainability due to the use of ethoxylated and sulfated surfactants, which can inhibit the effectiveness of microbiostatic and microbiocidal ingredients, and are often not environmentally friendly or appealing to consumers seeking natural products.
Innovation Solution
Development of biobased polyglyceryl ester compositions that form stable, transparent aqueous solutions without inhibiting the activity of microbiostatic/microbiocidal compounds, using a precise balance of hydrophilic and lipophilic characteristics, and excluding ethoxylates and sulfated surfactants, resulting in formulations that are clear, effective, and sustainable.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Illumination intensity
If ethoxylated surfactants are used to achieve clarity and solubilization, then transparent formulations are obtained, but antimicrobial activity is inhibited and environmental sustainability is compromised
Solution Approach 1:
The patent changes the chemical parameters of the surfactant by using polyglyceryl esters with specific hydrophilic-lipophilic balance values (HLB 3-20) and controlled molecular weights (100-1000 Da), replacing ethoxylated surfactants. This parameter change maintains formulation clarity while preserving antimicrobial activity because the polyglyceryl ester structure does not interfere with the mechanism of action of microbiostatic and microbiocidal ingredients.
Solution Approach 2:
The patent employs composite surfactant systems combining polyglyceryl esters with complementary properties to achieve both clarity and antimicrobial preservation. The formulation integrates multiple components including polyglyceryl esters, co-surfactants, and active ingredients in specific ratios to create a synergistic effect that maintains transparency while protecting antimicrobial efficacy.
2Illumination intensity
If ethoxylated surfactants are used to achieve clarity and solubilization, then transparent formulations are obtained, but environmental sustainability is compromised
Solution Approach 1:
The patent changes the source and chemical structure parameters of surfactants from petrochemical-based ethoxylates to biobased polyglyceryl esters derived from renewable resources. This parameter change achieves formulation clarity while improving environmental sustainability through biodegradability and reduced toxicological impact, as polyglyceryl esters are naturally metabolized by microorganisms compared to persistent ethoxylated compounds.
Solution Approach 2:
The patent adopts biodegradable polyglyceryl esters that can be naturally decomposed by microorganisms, replacing persistent ethoxylated surfactants. The polyglyceryl ester structure is designed to be environmentally friendly and readily biodegradable, aligning with the principle of using temporary, non-persistent materials that do not accumulate in the environment, thereby improving sustainability while maintaining clarity.
3Illumination intensity
If nonionic surfactants are used to solubilize water-insoluble ingredients, then clear formulations are achieved, but microbiostatic and microbiocidal ingredients are inactivated
Solution Approach 1:
The patent changes the surfactant parameters by selecting polyglyceryl esters with specific HLB values (3-20) and molecular weights (100-1000 Da) that provide adequate solubilization for clarity while avoiding the micelle formation and sequestration effects that inactivate antimicrobial ingredients. The controlled parameters prevent excessive micellar aggregation that would trap and protect microbiostatic compounds from their active sites.
Solution Approach 2:
The patent uses polyglyceryl esters as intermediary surfactants that mediate between the need for clarity through solubilization and the need to preserve antimicrobial activity. Unlike traditional nonionic surfactants that form stable micelles and sequester active ingredients, the polyglyceryl esters provide a balanced interface that allows water-insoluble ingredients to be solubilized without creating a protective micellar barrier around microbiostatic compounds, thus preserving their activity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biobased polyglyceryl ester compositions create clear, effective oral rinse formulations that maintain antimicrobial activity while being environmentally sustainable and appealing to consumers, offering improved clarity and preservation efficacy without the drawbacks of traditional surfactants.
Implementation Method 1
PGEs comprised of hydrophilic PG groups linked to lipophilic/hydrophobic fatty acyl groups by ester bonds demonstrate surface and interfacial activity due to their amphiphilic structures
Implementation Method 2
PGEs demonstrate surface and interfacial activity due to their amphiphilic structures
Implementation Method 3
PGEs may be employed as surfactants for the solubilization or microemulsification of water-insoluble species in aqueous media to yield stable, clear, i.e. transparent, solutions
Implementation Method 4
The biobased polyglyceryl ester compositions as described herein possess a precise balance between the hydrophilic and lipophilic characteristics of the polyglyceryl ester, which enables them to form stable, transparent aqueous solutions that do not inhibit the activity of microbiostatic/microbiocidal compounds
Data Source
AI summary
The present invention relates to oral rinse formulations comprising polyglyceryl ester compounds and processes for preparing same. The inventive oral rinse formulations may comprise water, at least one oral care benefit ingredient, and a mixture including one or more compounds of Formula (I):wherein: PG is a polyglyceryl group comprising greater than 40% hexaglycerol and higher polyglycerols and less than 60% pentaglycerol and lower polyglycerols,R is a linear or branched Cs-Cs alkyl group,n = from 1 to 3. The oral rinse formulations, which may be biobased, are devoid of ethoxylates and sulfonated surfactants. Processes of preparing a transparent oral rinse formulation are also disclosed.