Polyglycolide Nonwoven Reinforcement for Stretchable Tissue Adhesion
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Solution Overview
Problem
Conventional bioabsorbable non-woven fabrics for tissue reinforcement lack sufficient stretchability and water absorbency, which hinders their effectiveness in reinforcing tissues that expand and contract, such as the lungs and stomach, and limits their ability to contain fibrin glue for secure adhesion.
Innovation Solution
A non-woven fabric containing polyglycolide with specific average fiber diameter, areal density, and flexural rigidity ranges, produced by melt blowing and needle punching, to enhance stretchability and water absorbency, allowing for better tissue conformability and adhesion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If thin bioabsorbable non-woven fabrics with smaller average fiber diameters are used to enhance cell penetrability and conformability, then cell penetrability and conformability are improved, but stretchability is insufficient
Solution Approach 1:
The patent optimizes the average fiber diameter parameter to a specific range (0.5-7.0 μm) and areal density parameter (1.0-50 g/m2) to achieve the desired balance between cell penetrability, conformability, and stretchability. This parameter optimization allows the material to be thin enough for cell penetration while maintaining sufficient stretchability for tissue reinforcement.
2Adaptability or versatility
If thin bioabsorbable non-woven fabrics are used to improve conformability to irregularities, then conformability is enhanced, but water absorbency is insufficient for containing fibrin glue
Solution Approach 1:
The patent optimizes the areal density parameter within the range of 1.0-50 g/m2 to achieve the desired balance between conformability and water absorbency. This parameter optimization ensures the material is thin enough to conform to tissue irregularities while maintaining sufficient water absorbency to contain fibrin glue for secure adhesion.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting tissue reinforcement material provides high stretchability and water absorbency, ensuring secure adhesion with fibrin glue and improved tissue regenerating properties, particularly for tissues prone to expansion and contraction.
Implementation Method 1
tissue reinforcement materials made of thin bioabsorbable non-woven fabrics are not much water absorptive, and this makes it difficult for them to contain enough fibrin glue
Implementation Method 2
They are decomposed after a certain period and absorbed in the living body, thus advantageously eliminating the need for removal by another operation
Data Source
AI summary
The present invention aims to provide a tissue reinforcement material having water absorbency and high stretchability. Provided is a tissue reinforcement material including a non-woven fabric containing polyglycolide, wherein the tissue reinforcement material has an average fiber diameter of 0.5 μm or more and 7.0 μm or less, an areal density of 1.0 g/m2 or more and 50 g/m2 or less, and a flexural rigidity (B value) measured with a pure bending tester of 0.001 gf·cm2/cm or more and 0.01 gf·cm2/cm or less.