Polygodial Plant Extract for Wound Healing
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Solution Overview
Problem
Current treatments for skin disorders such as scars and stretch marks, including silicone, corticosteroids, retinoids, and hyaluronic acid, often cause irritation, side effects, and require lengthy occlusive use or expensive specialist interventions, lacking effective, non-phototoxic, and non-irritating alternatives.
Innovation Solution
A plant extract obtained from Tasmannia lanceolata, Drimys winteri, and Polygonum hydropiper using supercritical CO2 extraction at specific pressures and temperatures, containing polygodial, which is formulated into a composition for topical application to promote wound healing and reduce inflammation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional treatments (silicone, corticosteroids, retinoids, hyaluronic acid) are used for skin disorders, then wound healing is promoted, but irritation and side effects occur
Solution Approach 1:
The patent changes the chemical parameters of the treatment by using polygodial extracted from specific plants (Tasmannia lanceolata, Drimys winteri, Spilanthes acmella, or Polygonum hydropiper) at controlled concentrations (0.01-10% in cosmetic compositions, 0.1-5% in dermatological compositions). This natural compound alternative modifies the treatment parameters to achieve wound healing without the harmful side effects of traditional synthetic treatments.
Solution Approach 2:
The patent employs a naturally-derived, biodegradable alternative (polygodial from plant extracts) that replaces long-term, potentially harmful synthetic treatments. The natural extract provides effective wound healing with transient action, eliminating the need for prolonged occlusive use required by silicone treatments and avoiding cumulative side effects.
2Reliability
If occlusive treatments are used for skin disorders, then wound healing is promoted, but lengthy application time is required
Solution Approach 1:
The patent extracts and concentrates the active healing component (polygodial) from plant materials into a potent, ready-to-apply formulation. This extraction process creates a highly active composition that delivers therapeutic effects quickly without requiring lengthy occlusive application periods, unlike traditional silicone-based treatments.
3Reliability
If specialist interventions are used for skin disorders, then treatment effectiveness is improved, but treatment cost increases
Solution Approach 1:
The patent creates a self-administerable topical composition containing polygodial that patients can apply themselves without requiring expensive specialist interventions. The natural plant extract formulation provides effective wound healing and anti-inflammatory action that eliminates the need for costly clinical procedures while remaining accessible to consumers.
4Object-affected harmful factors
If polygodial is extracted from plants, then non-phototoxic and non-irritating alternative is obtained, but extraction process complexity increases
Solution Approach 1:
The patent identifies four different plant sources (Tasmannia lanceolata, Drimys winteri, Spilanthes acmella, Polygonum hydropiper) that all contain polygodial, providing universal access to this safe, effective compound. This multi-source approach allows selection based on availability and extraction efficiency, managing process complexity while ensuring consistent quality and safety profiles.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The extract demonstrates novel wound healing and anti-inflammatory activities, reducing skin irregularities and stretch marks depth, color, and improving dermal density without the side effects of traditional treatments, as shown by HPLC-DAD profiles, clinical scores, and ultrasound measurements.
Implementation Method 1
extracting leaves or berries, preferably leaves, from said plant with supercritical CO2 at a pressure of between 120 and 350 bar, preferably between 150 and 285 bar, and at a temperature of between 35 and 60° C., preferably between 40 and 50° C.
Data Source
AI summary
An extract of a plant chosen from Tasmannia lanceolata, Drimys winteri, Spilanthes acmella and Polygonum hydropiper is obtained from ground and dried leaves of said plant by supercritical CO2 extraction at a pressure of between 120 and 350 bar and at a temperature from 35 to 60° C. and contains polygodial. A process for obtaining such an extract is disclosed along with compositions comprising, in a physiologically acceptable medium, an effective amount of the extract to promotes wound healing and decrease inflammation in skin disorders.