Polygonum capitatum Extract Preparation via Dual-Solvent Merging
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Solution Overview
Problem
Current methods for extracting Polygonum capitatum yield varying effective ingredients due to different extraction methods, leading to inconsistent medicinal products, and there is a need for more effective hypoglycemic treatments.
Innovation Solution
A method involving ethanol and water extraction of Polygonum capitatum, where the plant is soaked in 55-65% ethanol and then decocted in water, followed by concentration and mixing of extracts to achieve a crude drug equivalent of 0.8-1.2 g/ml, which is then used to prepare tablets, capsules, granules, and oral liquids with specific ratios of ingredients to enhance hypoglycemic effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If different extraction methods are used for Polygonum capitatum, then the extraction process can be simplified, but the effective ingredients and contents become inconsistent
Solution Approach 1:
The patent combines multiple extraction methods (ethanol extraction and water decoction) into a single integrated process. The ethanol extraction is followed by water decoction of the residue, and the two extracts are merged and concentrated together. This combining approach maintains the simplicity of individual methods while achieving consistent and comprehensive extraction of effective ingredients through synergistic effect.
Solution Approach 2:
The patent optimizes extraction parameters including ethanol concentration (55-65%), extraction time (1-2 hours), water amount (10-14 times the drug residue amount), and decoction time (1-2 hours). By precisely controlling these parameters, the method ensures consistent extraction of effective ingredients while maintaining process simplicity.
2Ease of manufacture
If traditional extraction methods are used for Polygonum capitatum, then the preparation process is simpler, but the hypoglycemic effectiveness is insufficient
Solution Approach 1:
The patent segments the extraction process into distinct stages: ethanol extraction stage, water decoction stage, and combination concentration stage. Each stage targets different components, with ethanol extracting lipophilic compounds and water extracting hydrophilic compounds. This segmentation ensures comprehensive extraction of hypoglycemic active ingredients while maintaining a systematic and manageable preparation process.
Solution Approach 2:
The patent creates a composite extract containing both ethanol-soluble and water-soluble components. The final extract is a composite mixture that includes diverse chemical compounds from different solubility classes, enhancing the overall hypoglycemic effectiveness compared to single-solvent extraction methods.
3Reliability
If the extract concentration is increased to improve hypoglycemic effects, then the therapeutic effectiveness improves, but the extract viscosity and preparation difficulty increase
Solution Approach 1:
The patent employs continuous concentration process where the extract is concentrated through multiple stages (evaporation, filtration, and final concentration to 0.8-1.2 g/ml). This continuous action maintains the extract's therapeutic effectiveness while managing viscosity through controlled concentration steps and proper equipment design.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method results in a Polygonum capitatum extract that improves insulin resistance and glucose uptake in 3T3-L1 fat cells, demonstrating significant hypoglycemic effects and improved bioavailability through controlled preparation methods.
Implementation Method 1
add 55 ̃65% ethanol soak, and extract via reflux; the drug residue shall be decocted in water; Mix the concentrated alcohol extract liquid and the concentrated water extract liquid
Implementation Method 2
extract via reflux
Implementation Method 3
the drug residue shall be decocted in water
Implementation Method 4
concentrate it, to obtain the concentrated alcohol extract liquid; the decoction liquid is filtered and concentrated; concentrate it again, to obtain the Polygonum capitatum extract
Data Source
AI summary
This invention relates to the preparation of the Polygonum capitatum extract and its application and preparation containing the Polygonum capitatum extract thereof, belonging to the technical field of Traditional Chinese Medicine. The Polygonum capitatum extract is prepared by the following steps: take the dried Polygonum capitatum, add the 55˜65% ethanol to the dried Polygonum capitatum, soak and extract via reflux, and filter and concentrate it to get the concentrate alcohol extract; The drug residue after the alcohol extraction shall be decocted in water, filter and concentrate the water extract, to get the concentrated water extract; merge the concentrated alcohol extract and the concentrated water extract liquid, then concentrate the mixture to obtain the Polygonum capitatum extract. The Polygonum capitatum extract can be made into tablets, capsules, granules and oral liquid.