Polygonum Multiflori Extract Composition for Sarcopenia Muscle Loss

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Solution Overview

Problem

There are no effective drugs to treat sarcopenia, and existing treatments for other diseases are being repurposed, which may not adequately address muscle weakness and mobility issues associated with aging and muscular diseases.

Innovation Solution

A composition comprising Polygonum multiflorum Thunberg extract or its compound (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside, THSG) is used as an active ingredient to enhance exercise performance, increase muscle mass, and improve muscle function or treat muscular diseases such as sarcopenia.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing drugs for other diseases are repurposed for sarcopenia treatment, then treatment options are available, but they do not adequately address muscle weakness and mobility issues

Engineering Contradiction:

Improvetreatment effectivenessVSAvoiddisease-specific optimization

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent changes the chemical parameter by using a specific natural compound (Polygonum multiflorum extract or THSG) with defined molecular structure and pharmacological properties, rather than repurposing existing drugs. This specific compound demonstrates superior effectiveness in treating sarcopenia-related muscle weakness and mobility issues through its unique mechanism of action on muscle tissue.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If muscle mass decreases with aging, then sarcopenia occurs, but no approved drugs exist to treat it

Engineering Contradiction:

Improvetreatment availabilityVSAvoiddrug development complexity

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent utilizes a natural compound (Polygonum multiflorum extract/THSG) that occurs in nature, eliminating the need for complex synthetic drug development processes. The compound can be extracted and purified from the plant source using standard phytochemical extraction methods, providing a readily available treatment option for sarcopenia without requiring extensive pharmaceutical manufacturing infrastructure.

Inventive Principle:

Principle #25Self-service

3Strength

If Polygonum multiflorum Thunberg extract is used as active ingredient, then muscle strength and mass increase, but the composition requires specific extraction and formulation

Engineering Contradiction:

Improvemuscle strengthVSAvoidcomposition formulation

Core Design Contradiction:

StrengthVSDevice complexity

Solution Approach 1:

The patent extracts the active therapeutic compound (THSG or related compounds) from the Polygonum multiflorum Thunberg plant material through solvent extraction processes. This isolation of the specific active ingredient from the complex plant matrix enables the compound to be formulated into various dosage forms while maintaining its muscle-building efficacy, resolving the contradiction between therapeutic benefit and formulation complexity.

Inventive Principle:

Principle #2Taking out (Extraction)

Data Source

PatentUS20260021155A1Composition for enhancing exercise performance, increasing muscle mass, improving muscle functions, or preventing or treating muscular disease containing Polygonum multiflorum Thunberg extract

Publication Date: 2026.01.22 KOREA INST OF SCI & TECH

AI summary

The present invention relates to a composition for enhancing exercise performance, increasing muscle mass, improving muscle function, or preventing or treating muscular disease, comprising Polygonum multiflorum Thunberg extract. The extract of the present invention has the effect of enhancing muscle strength, increasing muscle mass, improving exercise performance, and the like.