Poly-herbal Composition for Broad-Spectrum Efficacy

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Solution Overview

Problem

Current herbal medicine formulations primarily focus on single plant extracts or aggregation of individual properties, lacking synergistic studies that could enhance drug efficacy and address broad-spectrum efficacy, safety, cost-effectiveness, and environmental considerations for anticancer, antiviral, and anti-inflammatory effects.

Innovation Solution

A poly-herbal synergistic composition combining Azardiracta indica, Citrus sinensis, Zea mays, Origanum vulgare, and other herbs, processed to nano-sized particles for enhanced bioavailability, exhibiting marked immunomodulatory, anticancer, and anti-inflammatory properties.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If single plant extracts or aggregation of individual properties are used, then the formulation is simple to manufacture, but the drug efficacy and broad-spectrum applicability are limited

Engineering Contradiction:
Improvebroad-spectrum efficacyVSAvoidformulation complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent combines multiple plant extracts (Aloe vera, Azadirachta indica, Citrus sinensis, Zea mays, Origanum vulgare, and other herbs) into a single poly-herbal composition. This merging of multiple botanical sources creates synergistic effects that provide broad-spectrum anticancer, antiviral, and anti-inflammatory properties while maintaining a unified formulation structure that is relatively simple to manufacture and administer.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite herbal formulation where different plant extracts are combined in specific proportions (each extract at 5-20% v/v) to achieve enhanced therapeutic effects. The composite nature of the formulation allows it to address multiple disease targets simultaneously, providing adaptability across different cancer types and viral infections while maintaining manufacturing simplicity through standardized extraction and mixing processes.

Inventive Principle:
Principle #40Composite materials

2Adaptability or versatility

If herbal formulations are developed for broad-spectrum efficacy, then the therapeutic coverage is enhanced, but the production cost and manufacturing complexity increase

Engineering Contradiction:
Improvebroad-spectrum efficacyVSAvoidproduction simplicity
Core Design Contradiction:
Adaptability or versatilityVSEase of manufacture

Solution Approach 1:

The patent segments the formulation into distinct plant extract components, each contributing specific therapeutic properties. This segmentation allows for standardized extraction and quality control of individual herbs, which can then be combined in predetermined ratios (5-20% v/v each). The segmented approach simplifies manufacturing by enabling modular production of individual extracts before final formulation, reducing overall production complexity despite the multi-component nature of the broad-spectrum formulation.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The invention optimizes the concentration parameters of each plant extract within a specific range (5-20% v/v) to achieve broad-spectrum efficacy while maintaining cost-effectiveness. By establishing standardized concentration parameters for each component, the formulation achieves therapeutic versatility without requiring complex customization during manufacturing. This parameter optimization allows for scalable production with consistent quality across different batches.

Inventive Principle:
Principle #35Parameter changes

3Reliability

If multiple herbs are combined in synergistic composition, then the drug efficacy is enhanced, but the formulation complexity and processing requirements increase

Engineering Contradiction:
Improvedrug efficacyVSAvoidformulation complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The poly-herbal composition is designed with multi-functionality, where each plant extract contributes to multiple therapeutic effects. For example, Aloe vera provides both anticancer and immunomodulatory properties, while Azadirachta indica contributes antiviral and anti-inflammatory effects. This universal approach allows a single formulation to address multiple disease mechanisms simultaneously, enhancing reliability of efficacy without requiring separate formulations for different conditions, thereby reducing overall formulation complexity.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent performs preliminary extraction and standardization of each plant component before final formulation. Individual extracts are prepared in advance with controlled concentrations and quality parameters, then combined in the final synergistic composition. This preliminary action ensures consistent efficacy of each component while simplifying the final formulation process, as the individual extracts are already optimized and ready for combination without requiring complex processing at the final stage.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentUS20230134228A1Synergistic herbal composition as a broad-spectrum prophylactic major and method to prepare the same
Publication Date: 2023.05.04 SINGH PAWAN KUMAR
  • US20230134228A1 patent drawing
  • US20230134228A1 patent drawing
  • US20230134228A1 patent drawing

AI summary

Disclosed herein are formulations of a poly-herbal synergistic composition which exhibit marked immunomodulatory, anticancer, antiviral and anti-inflammatory properties. Also disclosed are the methods of preparing and using the same.