Polyherbal Local Anaesthetic Formulation for Rapid, Lasting Action
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Solution Overview
Problem
Existing herbal formulations do not possess the desired properties of rapid onset, prolonged duration, steady decline, and lack of side effects for effective local anesthesia, making them unsuitable for minor surgeries and procedures.
Innovation Solution
A polyherbal formulation using hydroalcoholic extracts of Syzygium aromaticum, Aconitum heterophyllum, Myristica fragrans, Aconitum ferox, Acmella ciliate, and essential oils of Syzygium aromaticum and Nigella sativa, with alginate as an emulsifying agent, is developed to achieve rapid onset, prolonged duration, and minimal side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If clove/clove oil is used as a local anaesthetic, then rapid onset of action is achieved, but duration of action is too short (declines within a few minutes)
Solution Approach 1:
The patent combines multiple herbs (Syzygium aromaticum, Aconitum heterophyllum, Myristica fragrans, Aconitum ferox, Acmella ciliate, and Nigella sativa) into a polyherbal formulation. This merging of multiple substances with different pharmacological profiles allows the formulation to achieve both rapid onset (from clove-like compounds) and prolonged duration (from other herbs with sustained anaesthetic activity), resolving the contradiction between quick action and lasting effect.
Solution Approach 2:
The invention creates a composite anaesthetic formulation containing multiple herbal extracts and essential oils in specific concentrations. This composite approach integrates the rapid-acting components (similar to clove) with sustained-acting components, achieving a balanced pharmacological profile that simultaneously provides fast onset and extended duration of action, overcoming the limitations of single-herb formulations.
2Duration of action of moving object
If conventional local anaesthetics are used, then desired duration of action is achieved, but side effects occur and recovery requires acclimatisation time
Solution Approach 1:
The patent transforms the potential harm of strong anaesthetic agents (which cause side effects and require recovery time) into a benefit by using natural herbal compounds with milder, more balanced pharmacological profiles. The polyherbal formulation maintains sufficient anaesthetic duration while avoiding the harmful side effects and prolonged recovery associated with conventional synthetic anaesthetics, converting a harmful characteristic into a beneficial one.
Solution Approach 2:
The invention changes the pharmacological parameters of the anaesthetic formulation by using natural herbal extracts instead of conventional synthetic drugs. This parameter change results in a formulation that provides adequate duration of action while having fewer side effects and faster recovery, altering the fundamental characteristics of the anaesthetic agent to achieve better safety and recovery profiles.
3Device complexity
If single herb formulations are used, then simplicity of formulation is maintained, but desired pharmacological properties (rapid onset, prolonged duration, steady decline) are not achieved
Solution Approach 1:
The patent merges six different herbs into a single polyherbal formulation, each contributing specific pharmacological properties. This combining approach achieves reliable and consistent pharmacological performance (rapid onset, prolonged duration, steady decline) that cannot be obtained with single-herb formulations, while the formulation remains relatively simple to prepare using standard extraction and emulsification techniques.
Solution Approach 2:
The polyherbal formulation exhibits multi-functionality by simultaneously achieving rapid onset, prolonged duration, and steady decline phases in a single formulation. This universal performance profile satisfies multiple pharmacological requirements that would otherwise require separate substances, demonstrating that the combined herbal system can perform multiple functions that single herbs cannot achieve independently.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation demonstrates early onset, prolonged action lasting up to 50 minutes, smooth recovery, and no significant side effects, making it an ideal replacement for conventional local anesthetics like lignocaine.
Implementation Method 1
The polyherbal formulation disclosed in this specification was formulated using the hydroalcoholic extract viz., of herbs, Syzygium aromaticum, Aconitum heterophyllum, Myristica fragrans, Aconitum ferox and Acmella ciliate along with the essential oil of Syzygium aromaticum and Nigella sativa
Implementation Method 2
Alginate was used as the emulsifying agent (extracted from brown algae)
Data Source
AI summary
The invention disclosed herein describes a polyherbal local anaesthetic formulation and a method of preparation. The polyherbal anaesthetic formulation was formulated using the hydroalcoholic extract of herbs, viz., Syzygium aromaticum, Aconitum heterophyllum, Myristica fragrans, Aconitum ferox and Acmella ciliate along with the essential oil of Syzygium aromaticum and Nigella sativa. Alginate was used as the emulsifying agent (extracted from brown algae). The invention also discloses method of preparing the polyherbal formulation.