Polyhexanide Chewing Gum for Periodontal Pocket Delivery
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Solution Overview
Problem
Current treatments for periodontal, peri-implant, and other bacterial and viral diseases in the mouth and throat, such as gingivitis and periodontitis, are ineffective due to the inaccessibility of the periodontal/peri-implant pocket and systemic administration issues, with existing antibacterial agents causing side effects, requiring high concentrations, and having short shelf lives and allergenic potential.
Innovation Solution
An oral delivery system utilizing polyhexanide in a solid form, particularly as a chewing gum, chip or film, which provides a slow release of the antimicrobial agent directly to the gingival pockets, allowing prolonged contact and reducing the need for high concentrations, while being non-cytotoxic and non-irritant.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antibacterial agents (chlorhexidine, quaternary ammonium salts) are used in mouth rinses, then prophylaxis and treatment of infectious pathological changes is achieved, but side effects occur (discoloration, bad taste, disturbance of wound healing, systemic absorption, toxic metabolites, allergenic potential, irritant effects)
Solution Approach 1:
The patent changes the chemical parameter of the antibacterial agent from conventional agents like chlorhexidine and quaternary ammonium salts to polyhexanide, which has different chemical properties. This parameter change results in reduced side effects while maintaining effectiveness, as polyhexanide does not cause discoloration, has acceptable taste, does not disturb wound healing, and produces no toxic metabolites
Solution Approach 2:
The patent uses polyhexanide, a polymeric compound, as the active ingredient in the oral delivery system. This composite material approach allows for controlled release and reduced systemic absorption compared to small molecule antibacterial agents, while maintaining effectiveness against periodontal pathogens
2Reliability
If conventional antibacterial agents are used at high concentrations to achieve corresponding effect, then effectiveness is improved, but cost and potential harm increase
Solution Approach 1:
By changing to polyhexanide as the active ingredient, the patent achieves effective treatment at lower concentrations compared to conventional agents like chlorhexidine. The polymeric structure and release characteristics of polyhexanide allow for sustained activity at reduced dosage levels
3Reliability
If the periodontal/peri-implant pocket is made accessible for direct application, then treatment effectiveness is improved, but the complexity of the procedure increases
Solution Approach 1:
The patent employs a chewing gum formulation that the patient self-administers by chewing and allowing it to dissolve in the oral cavity. This self-service approach enables direct delivery of polyhexanide to the periodontal pocket without requiring professional intervention or complex application procedures, while achieving effective treatment
4Adaptability or versatility
If systemic administration of antibiotics is used, then treatment coverage is improved, but effectiveness against periodontal diseases remains low
Solution Approach 1:
The patent delivers polyhexanide directly to the periodontal pocket through oral administration of chewing gum, achieving high local concentration at the site of infection. This local delivery approach overcomes the limitation of systemic antibiotics by concentrating the therapeutic agent where it is most needed, thereby improving effectiveness despite reduced overall treatment coverage
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The oral delivery system effectively treats and prevents infectious pathological changes with prolonged contact, avoiding side effects and resistance, and maintaining effectiveness at lower concentrations, with a longer shelf life and reduced protein and blood interference.
Implementation Method 1
which can be introduced into the periodontal cavity and slowly release an antimicrobial agent
Implementation Method 2
The oral delivery system according to the invention is in a solid pharmaceutical form... in the form of a chewing gum, chip or film
Data Source
AI summary
The present invention provides a delivery system for the treatment and/or prevention of infectious pathological changes, including compositions comprising polyhexanide, various pharmaceutical formulations, and processes for using these formulations in oral treatment modalities.