Nicotinic Acid Polyhydroxy Ester Production With 1-Alkylimidazole
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Solution Overview
Problem
Existing methods for producing polyhydroxy esters of nicotinic acid, such as inositol hexanicotinate, involve the use of pyridine as a solvent, which poses environmental and occupational hazards and is economically disadvantageous.
Innovation Solution
A process for producing polyhydroxy esters of nicotinic acid using 1-alkylimidazole as a solvent in an ionic liquid, eliminating the need for pyridine and enabling a more efficient and environmentally friendly reaction by forming a clear solution that is easier to handle and purify.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If pyridine is used as a solvent in the production of polyhydroxy esters of nicotinic acid, then the reaction can proceed effectively, but environmental and occupational hazards increase and economic costs rise
Solution Approach 1:
The patent removes pyridine from the reaction system entirely and replaces it with 1-alkylimidazole as a new solvent. This extraction of the harmful substance (pyridine) eliminates the environmental and occupational hazards associated with it while maintaining the reaction's effectiveness through the alternative solvent system.
Solution Approach 2:
The patent employs 1-alkylimidazole, which forms ionic liquids that can be easily separated and recovered from the reaction mixture. This replaces the expensive and hazardous pyridine system with a more economical and environmentally friendly alternative that achieves the same reaction effectiveness without the harmful side effects.
2Ease of manufacture
If pyridine is used as a solvent, then the reaction mixture can be formed, but handling and purification become more difficult
Solution Approach 1:
The patent changes the physical and chemical parameters of the solvent system by using 1-alkylimidazole, which forms ionic liquids with distinct properties. These ionic liquids exhibit different solubility characteristics, boiling points, and separation behaviors compared to pyridine, making the reaction mixture easier to handle and the purification process more straightforward.
Solution Approach 2:
The ionic liquids formed by 1-alkylimidazole undergo phase transitions that facilitate separation from the reaction products. The distinct phase behavior of these ionic liquids allows for easier filtration, decantation, or distillation processes compared to the pyridine system, thereby simplifying both handling and purification operations.
3Productivity
If traditional methods are used to produce polyhydroxy esters of nicotinic acid, then the reaction can be carried out, but residual solvent remains in the product and environmental impact increases
Solution Approach 1:
The patent converts the potential harm of solvent residue into a benefit by using 1-alkylimidazole, which forms ionic liquids that can be completely removed or easily separated from the final product. The unique properties of these ionic liquids allow for more thorough purification, converting what would normally be a contamination issue into an advantage where minimal residual solvent remains in the product.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process achieves high yields of colorless polyhydroxy esters, such as inositol hexanicotinate, with minimal residual solvent, reducing environmental impact and operational costs while enhancing reaction fluidity and simplifying purification.
Implementation Method 1
A process for producing polyhydroxy esters of nicotinic acid using 1-alkylimidazole as a solvent in an ionic liquid
Implementation Method 2
Process for producing polyhydroxy esters of nicotinic acid by reacting polyhydroxy alcohol and nicotinic acid
Data Source
AI summary
There is disclosed a process for the production of polyhydroxy esters of nicotinic acid by carrying out the esterification reaction of polyhydroxy alcohol and nicotinic acid in the presence of 1-alkylimidazole.