Polymannan Extract Composition for Immune Stimulation
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Solution Overview
Problem
Current treatments for various cancers such as leukemias, lymphomas, prostate cancer, breast cancer, and colon cancer lack effective immunomodulatory agents that can stimulate the immune system to target and eliminate cancer cells efficiently.
Innovation Solution
A method for preparing a fine powder of polymannan extract from Aloe species, involving steps like freeze-drying, dissolving in water, adding an organic solvent, centrifugation, and lyophilization, which is then used as an immunomodulating agent in pharmaceutical compositions to stimulate the immune system and increase natural killer cells, thereby treating cancers and immune disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current cancer treatments are used, then cancer cells can be targeted, but the immune system cannot be effectively stimulated to eliminate cancer cells efficiently
Solution Approach 1:
The patent extracts and isolates specific polysaccharide fractions (acemannan, aloemannan, aloeride) from Aloe vera that possess immunomodulatory properties. This extraction process separates the beneficial immunostimulating components from the rest of the plant material, creating concentrated compositions that can effectively stimulate the immune system to target and eliminate cancer cells.
Solution Approach 2:
The patent creates composite pharmaceutical compositions that combine multiple polysaccharide fractions (acemannan, aloemannan, aloeride) with specific molecular weight ranges and compositional ratios. These composite materials synergistically enhance immune system stimulation while maintaining safety and efficacy for cancer treatment.
2Reliability
If polysaccharide fractions are isolated from Aloe vera, then immunostimulatory activity is achieved, but the molecular weight and compositional complexity must be precisely controlled
Solution Approach 1:
The patent specifies precise parameter ranges for the polysaccharide fractions, including molecular weight (acemannan: 500,000-2,000,000 Daltons, aloemannan: 100,000-500,000 Daltons, aloeride: 2,000,000-10,000,000 Daltons), sugar composition ratios, and acetyl content (1-10%). These controlled parameters ensure consistent immunostimulatory activity while providing clear manufacturing specifications.
3Adaptability or versatility
If pharmaceutical compositions are developed with specific polysaccharide fractions, then immunomodulation and cancer treatment are achieved, but the composition complexity and manufacturing requirements increase
Solution Approach 1:
The patent segments the complex Aloe vera polysaccharide mixture into distinct fractions (acemannan, aloemannan, aloeride) with specific molecular weight ranges and compositional characteristics. This segmentation simplifies the manufacturing process by providing clear isolation criteria and specification parameters for each fraction, making the overall composition development more manageable despite the versatility gained.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polymannan extract composition results in a 75-80% increase in natural killer cells and effectively treats leukemias, lymphomas, prostate cancer, breast cancer, and colon cancer by enhancing the immune system's ability to target and eliminate cancer cells, as evidenced by increased caspase 3 levels indicating apoptosis of cancer cells.
Implementation Method 1
dissolving the freeze-dried aloe powder in deionized water to form a solution
Implementation Method 2
adding an organic solvent to the solution to form a first mixture; allowing the first mixture to settle for at least 8 hours
Implementation Method 3
centrifuging the second mixture; observing for a presence of a precipitate in second mixture
Implementation Method 4
lyophilizing the frozen powder of the polymannan extract in a lyophilizer
Data Source
AI summary
The present invention describes a method for preparing a polymannan extract from freeze-dried aloe powder. The polymannan extract of the present invention is further used to formulate a sterile injectable formulation for the treatment of one or more cancers, leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer, immune diseases, particularly immune related neoplasms, acquired immune deficiency syndrome, and hepatitis C.