Polymer Coated Articles for Reliable Blood Coagulation Adhesion
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Solution Overview
Problem
Current measurement articles for coagulation testing face issues with insufficient blood adhesion to polymer surfaces, particularly in high thrombocyte concentrations, leading to misinterpretations and challenges in diagnosing hyperfibrinolysis, and require cost-effective quality control methods.
Innovation Solution
A polymer-based article with a specialized coating material is used to enhance blood adhesion, allowing for improved diagnostic specificity and easier quality control, where the coating material is applied to optimize surface properties independently of the article's body material.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If a polymer-based article is used for coagulation testing, then manufacturing cost and ease of production are improved, but blood adhesion to the surface deteriorates
Solution Approach 1:
The patent applies a coating layer comprising collagen or gelatin on the polymer-based article surface. This composite structure combines the manufacturing advantages of polymer materials with the superior blood adhesion properties of natural materials like collagen and gelatin, thereby resolving the contradiction between ease of manufacture and blood adhesion reliability.
2Ease of manufacture
If a polymer-based article is used for coagulation testing, then manufacturing cost is reduced, but diagnostic precision deteriorates due to misinterpretations
Solution Approach 1:
By coating the polymer article with collagen or gelatin, the surface properties are enhanced to provide reliable blood adhesion. This prevents misinterpretations in coagulation testing results, thereby maintaining diagnostic precision while retaining the cost advantages of polymer-based manufacturing.
3Productivity
If a polymer-based article is used for coagulation testing, then productivity is improved, but measurement precision deteriorates due to challenges in diagnosing hyperfibrinolysis
Solution Approach 1:
The collagen or gelatin coating on the polymer article surface ensures proper blood adhesion even in cases of high thrombocyte concentration or hyperfibrinolysis. This enables accurate measurement and diagnosis while maintaining the high productivity benefits of using disposable polymer-based articles.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The coated articles provide enhanced adhesion of coagulating and coagulated blood, reducing misinterpretations and improving diagnostic accuracy, especially in conditions with high thrombocyte content, while allowing for efficient and cost-effective quality assurance.
Implementation Method 1
enhance blood adhesion, allowing for improved diagnostic specificity
Data Source
AI summary
The present invention provides a coated article, which can be used in in-vitro diagnostics, in particular in the diagnostic testing of body fluids, such as in blood coagulation testing. The coated article is made of a polymer material and coated with a polymer material, which may be the same or different. The present invention furthermore provides a method of preparing such a coated article and a method of performing such diagnostics, e.g. coagulation analysis.