Polymer Anticoronaviral Agent for Coronavirus Envelope Penetration
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Solution Overview
Problem
There is a growing demand for antiviral agents that effectively target coronaviruses, particularly the novel coronavirus, as existing antiviral agents do not exhibit sufficient efficacy against these viruses.
Innovation Solution
An anticoronaviral agent comprising a polymer with specific structural units, including a structural unit derived from an amino group-containing monomer and a hydrophobic monomer, which penetrates the coronavirus envelope to achieve antiviral activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing antiviral agents are used, then general antiviral coverage is provided, but efficacy against coronaviruses is insufficient
Solution Approach 1:
The patent modifies the chemical structure of antiviral agents by incorporating specific amino group-containing structural units (formulae 1 and 2) with defined molecular parameters. This structural parameter change enables the polymer to specifically target coronavirus envelopes while maintaining stability, resolving the contradiction between specialized coronavirus efficacy and general antiviral coverage.
Solution Approach 2:
The invention creates a copolymer composite material combining structural units (a) with specific amino groups and structural units (b) with Hildebrand solubility parameters of 35 (MPa)1/2 or less. This composite structure integrates the antiviral activity of amino groups with the envelope-penetrating capability of hydrophobic units, achieving both high coronavirus efficacy and broad viral coverage.
2Reliability
If polymer concentration is increased to enhance antiviral activity, then antiviral efficacy improves, but water solubility may be compromised
Solution Approach 1:
The patent carefully controls the Hildebrand solubility parameter of structural unit (b) to be 35 (MPa)1/2 or less, and optimizes the overall polymer solubility parameter to 8-30 (MPa)1/2. This parameter optimization allows the polymer to maintain high water solubility even at effective concentrations, resolving the contradiction between antiviral activity and solubility stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polymer demonstrates strong antiviral activity against coronaviruses, particularly SARS-CoV-2, with enhanced efficacy due to the synergistic action of the structural units, maintaining safety and water solubility.
Implementation Method 1
a structural unit (b) having a Hildebrand solubility parameter of 35 (MPa)1/2 or less
Data Source
AI summary
An object of the present invention is to provide an anticoronaviral agent and the like. Provided is an anticoronaviral agent comprising a polymer comprising at least one type of structural unit (a) selected from a structural unit represented by the following general formula (1):a structural unit that is a salt of the general formula (1), and a structural unit represented by the following general formula (2):wherein in the general formulae (1) and (2), R1, R2, and R3 each independently represent a hydrogen atom or an alkyl group of 1 to 5 carbon atoms, R4 to R8 each independently represent a hydrogen atom or an organic group, X represents a divalent linking group, and Y− represents an anion.