Biodegradable Polymer Microparticles Plasma Surface Treatment
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Solution Overview
Problem
Biodegradable polymer microparticles for fillers face challenges with low dispersibility due to hydrophobicity, requiring excipients that increase viscosity and reduce longevity when injected into the body, leading to decreased treatment satisfaction.
Innovation Solution
A freeze-dried body comprising hydrophilic surface-treated biodegradable polymer microparticles with a plasma or base surface treatment, using a biocompatible carrier to enhance dispersibility and prevent self-aggregation, reducing the need for excipients and improving injection stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If excipient is added to improve dispersibility of biodegradable polymer microparticles, then dispersibility is improved, but viscosity increases and treatment longevity decreases
Solution Approach 1:
The patent applies surface treatment to the biodegradable polymer microparticles to change their surface properties from hydrophobic to hydrophilic. This parameter change in surface characteristics improves dispersibility without requiring excipients, thereby avoiding the viscosity increase that would otherwise be necessary to achieve adequate dispersibility.
Solution Approach 2:
The patent removes the excipient component from the filler composition entirely. By achieving adequate dispersibility through surface treatment of the microparticles alone, the formulation eliminates the need for excipients, thereby avoiding both viscosity increase and the longevity reduction that occurs when excipients are injected into the body.
2Stability of the object's composition
If excipient content is increased to maintain dispersibility, then dispersibility is maintained, but treatment duration decreases due to rapid decomposition
Solution Approach 1:
The patent removes excipients from the formulation entirely, relying solely on surface-treated microparticles. This eliminates the decomposition issue associated with excipients while maintaining dispersibility through the hydrophilic surface treatment, thereby preserving treatment duration.
Solution Approach 2:
By changing the surface properties of the microparticles through plasma or base treatment, the patent achieves adequate dispersibility without excipients. This parameter change in surface hydrophilicity ensures both maintained dispersibility and extended treatment duration by eliminating excipient decomposition.
3Duration of action of moving object
If biodegradable polymer microparticles are used without excipient, then treatment longevity is improved, but dispersibility decreases
Solution Approach 1:
The patent applies surface treatment (plasma or base treatment) to change the surface properties of the biodegradable polymer microparticles from hydrophobic to hydrophilic. This parameter change enables the microparticles to disperse adequately in the injection medium without requiring excipients, thereby achieving both improved treatment longevity and maintained dispersibility.
Solution Approach 2:
The patent replaces the mechanical/chemical role of excipients with a surface treatment process. Instead of using excipients to achieve dispersibility, the patent uses surface treatment to modify the microparticle properties directly, substituting one mechanism for another to achieve the same functional outcome without the adverse effects of excipients.
4Stability of the object's composition
If surface treatment is applied to improve hydrophilicity, then dispersibility is improved, but manufacturing complexity increases
Solution Approach 1:
The patent uses plasma treatment or base treatment to achieve surface modification. These are established industrial processes that can be efficiently applied to microparticles, providing a practical balance between achieving hydrophilic surface properties and maintaining manufacturing feasibility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution achieves excellent dispersibility and stability of biodegradable polymer microparticles in filler injections, allowing for effective use without excipients, maintaining treatment efficacy and reducing side effects by controlling particle size and surface treatment.
Implementation Method 1
the hydrophilic surface-treated biodegradable polymer microparticle is a plasma surface-treated product
Implementation Method 2
the hydrophilic surface-treated biodegradable polymer microparticle is a base surface-treated product using discharge
Implementation Method 3
freeze-drying the mixed solution to obtain a freeze-dried body
Data Source
AI summary
Disclosed herein are a biodegradable polymer microparticle for a filler, a freeze-dried body including the same, a manufacturing method thereof, and filler injection including the freeze-dried body. The freeze-dried body includes hydrophilic surface-treated biodegradable polymer microparticle and a biocompatible carrier, wherein the hydrophilic surface-treated biodegradable polymer microparticle has an average particle diameter (D50) of 20 to 50 μm and is polydioxanone which has a carboxyl group on the surface thereof. The hydrophilic surface-treated biodegradable polymer microparticle is a plasma surface-treated product or a base surface-treated product using discharge of the biodegradable polymer microparticle. The content of the biocompatible carrier is 1 to 5 parts by weight based on 100 parts by weight of the freeze-dried body.