Polymer Modified Porous Substrate for SPE
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Solution Overview
Problem
Existing polymeric sorbents for solid phase extraction are inconvenient and expensive to manufacture, and they do not provide effective retention of both polar and nonpolar analytes, nor do they allow for efficient recovery of analytes in small eluant volumes with superior flow rates.
Innovation Solution
A polymer modified porous substrate is developed, comprising a polymeric monolith formed on a porous substrate, which can be functionalized with polar moieties for enhanced retention of analytes, and is manufactured using a method involving hydrophobic monomers, porogenic solvents, and polymerization initiators, allowing for the formation of a monolith, agglomerated particles, or woven fibers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional polymeric sorbents are used for solid phase extraction, then manufacturing complexity and cost increase, but retention effectiveness for polar and nonpolar analytes remains insufficient
Solution Approach 1:
The patent creates a composite material by forming a polymeric monolith directly on a porous substrate, combining the structural support of the substrate with the sorptive properties of the polymer. This composite structure improves retention effectiveness while simplifying manufacturing compared to traditional separate sorbent particles and matrix systems.
Solution Approach 2:
The patent utilizes a porous substrate as the foundation for the polymeric monolith, creating a structure with controlled porosity that enhances analyte access and retention. The porous structure allows for efficient mass transfer while maintaining mechanical integrity, resolving the contradiction between effectiveness and manufacturing complexity.
2Productivity
If polymeric sorbents are used for solid phase extraction, then manufacturing cost increases, but analyte recovery efficiency in small eluant volumes remains insufficient
Solution Approach 1:
The patent merges the sorbent material and support structure into a single integrated polymeric monolith formed on the porous substrate. This eliminates the need for separate sorbent particles and matrix components, reducing manufacturing steps and costs while improving analyte recovery efficiency through optimized flow paths and reduced dead volume.
3Ease of operation
If conventional sorbent structures are used, then manufacturing simplicity is maintained, but flow rates and analyte recovery in small volumes are insufficient
Solution Approach 1:
The patent applies local quality by creating a polymeric monolith with specific sorptive properties on the porous substrate surface, while the substrate provides structural support and flow distribution. This localized functional differentiation improves flow rate performance and analyte recovery without requiring complex overall device architecture.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polymer modified porous substrate offers improved ease of use and manufacturing, superior retention of polar and nonpolar analytes, and efficient recovery with high flow rates, outperforming traditional sorbents in solid phase extraction applications.
Implementation Method 1
a polymeric monolith formed thereon, wherein the polymeric monolith has the formula <formula> wherein A is selected from C5-10 monocyclic or bicyclic aryl or heteroaryl
Implementation Method 2
a porous substrate and a polymeric monolith formed thereon
Implementation Method 3
a polymeric monolith formed thereon, wherein the polymeric monolith has the formula
Data Source
AI summary
A polymer modified porous substrate for solid phase extraction or chromatography, comprising a porous substrate and a polymeric monolith formed thereon, wherein the polymeric monolith comprises C5-10 monocyclic or bicyclic aryl or heteroaryl, optionally substituted with -L-Qp-Rq; where q is 0-3, p is 0-5, Q is —NRC(O)—, —C(O)NR—, —OC(O)NR—, —OC(O)R—, —NRC(O)O—, —NRC(O)NR—, —NCO, —CHOHCHOH—, CH2OCHCH2O—, —(CH2CH2O)s—, —(CH2CH2CH2O)s—, —C(O)—, —C(O)O—, —CH2C(O)CH2—, —S—, —SS—, —CHOH—, —O—, —SO—, —SO2—, —SO3—, —OSO3, —SO2NR—, —NRq—, and —NRq+—, —CN, —NC, —CHOCH—, —NHC(NH)NH—, —NO2, —NO, —OPO3—, —OH; and R is hydrogen, C5-10 monocyclic or bicyclic aryl or heteroaryl, C1-12 branched, unbranched, or cyclic hydrocarbyl; L is a bond or a C1-12 branched, unbranched, or cyclic hydrocarbyl. Methods of preparing and using the polymer modified porous substrates are disclosed.