Polymer Sorption Filter for Breath Analyte Differentiation

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Solution Overview

Problem

Current alcohol sensors, including handheld breath analyzers, fail to differentiate between ethanol and methanol, leading to undiagnosed methanol intoxication, and existing devices for detecting hydrogen and methane in breath are expensive, non-portable, and have low accuracy.

Innovation Solution

A compact, handheld device equipped with a polymer sorption filter that separates methanol from ethanol and hydrogen/methane from interferants, using a sorption filter with specific sorption capacity and strength to enable selective detection of these analytes, allowing for rapid and reliable diagnosis of methanol poisoning and intestinal disorders.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional alcohol sensors are used to detect methanol in breath, then the device can detect alcohol presence, but it cannot differentiate methanol from ethanol leading to false positives

Engineering Contradiction:
Improveanalyte differentiation capabilityVSAvoiddiagnosis accuracy
Core Design Contradiction:
Measurement precisionVSReliability

Solution Approach 1:

The detection system is segmented into two functional parts: a polymer sorption filter that selectively retains ethanol while allowing methanol to pass through, and a sensor that detects only the methanol component. This segmentation enables the system to differentiate between the two alcohols by physically separating them before detection.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The interfering ethanol component is extracted from the gas mixture by the polymer sorption filter, which selectively absorbs ethanol while permitting methanol to pass through to the detector. This extraction of the interfering substance enables accurate methanol detection despite the presence of ethanol in breath.

Inventive Principle:
Principle #2Taking out (Extraction)

2Ease of operation

If miniaturization is pursued to create a handheld device, then portability and ease of operation improve, but detection precision and reliability may deteriorate

Engineering Contradiction:
ImproveportabilityVSAvoiddetection accuracy
Core Design Contradiction:
Ease of operationVSMeasurement precision

Solution Approach 1:

A polymer sorption filter with controlled porosity is used to achieve selective separation of methanol and ethanol. The porous structure provides high surface area for sorption while maintaining compact dimensions, enabling effective separation in a miniaturized format that preserves both portability and detection precision.

Inventive Principle:
Principle #31Porous materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device allows for quick and accurate detection of methanol and hydrogen/methane down to 100 ppb within 2.5 minutes, independent of ethanol concentration, facilitating rapid screening and diagnosis of methanol poisoning and intestinal disorders, and can be used for monitoring treatment and beverage testing.

Implementation Method 1

The polymer sorption filter which ad- and/or absorbs ethanol stronger than methanol

Methodology Applied
Scientific EffectSorption: Sorption

Implementation Method 2

The polymer sorption filter which adsorbs and retains the interferants

Methodology Applied
Scientific EffectAdsorption: Adsorption

Implementation Method 3

The polymer sorption filter which ad- and/or absorbs ethanol stronger than methanol

Methodology Applied
Scientific EffectAbsorption: Absorption (physical)

Implementation Method 4

The polymer sorption filter, which adsorbs and retains the interferants, while hydrogen and methane are not affected as strong

Methodology Applied
Scientific EffectAdsorption: Adsorption

Data Source

PatentUS12196727B2Device and method for detecting an analyte
Publication Date: 2025.01.14 ETH ZURICH
  • US12196727B2 patent drawing
  • US12196727B2 patent drawing
  • US12196727B2 patent drawing

AI summary

The invention relates to a device (1) for detecting an analyte in a gas mixture or a liquid, comprising: (a) a polymer sorption filter (2) configured to separate methanol from ethanol; and/or to separate hydrogen and/or methane from interferants; and (b) means configured to detect (4) at least one of methanol, ethanol, hydrogen and methane. Furthermore, described is a method for detecting an analyte using the device and the use of the device.