Biocompatible Polymer Composition for In Vivo Vessel Repair
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing polymer compositions for in vivo vessel repair, such as aneurysm repair, face issues with unsatisfactory handling characteristics, high toxicity, low biocompatibility, high thrombogenicity, and insufficient durability, which hinder effective and safe treatment.
Innovation Solution
A biocompatible polymer composition with a specific viscosity range (2000-12,000 cSt at 25°C) is developed, comprising a matrix pre-polymer, filler, and curing agent, which is curable in an aqueous environment at 37°C, providing fast flowability for administration and rapid curing to form a material with high elongation and elastic modulus, ensuring durability and mechanical strength.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If the polymer composition has high flowability for swift administration, then the viscosity is low, but the curing time becomes too long and blood recirculation disconnection is prolonged
Solution Approach 1:
The patent applies parameter changes by carefully controlling the viscosity of the polymer composition within a specific range (2000-12000 cSt at 25°C) and optimizing the curing agent concentration (0.1-10 wt%) to achieve a balance between flowability for administration and curing speed to minimize blood recirculation disconnection time
Solution Approach 2:
The patent uses partial action by incorporating a curing agent at optimized concentrations (0.1-10 wt%) that provides sufficient curing speed without excessive reaction that would increase viscosity too much or cause harmful side effects, achieving the right balance between flowability and curing performance
2Loss of time
If the polymer composition cures rapidly to avoid prolonged disconnection of blood recirculation, then the curing time is short, but the handling characteristics become unsatisfactory
Solution Approach 1:
The patent optimizes the viscosity parameter within a specific range (2000-12000 cSt at 25°C) that provides both satisfactory handling characteristics for administration and adequate curing speed, resolving the contradiction between ease of operation and curing time
3Object-affected harmful factors
If the polymer composition has high biocompatibility and low toxicity, then the material is safe for in vivo use, but the mechanical strength and durability may be reduced
Solution Approach 1:
The patent uses composite materials by combining biocompatible polymers (such as polyethylene glycol, polypropylene glycol, or polycaprolactone) with curing agents and optionally fillers or reinforcement materials to achieve both high biocompatibility/low toxicity and adequate mechanical strength for vessel repair applications
Solution Approach 2:
The patent optimizes the molecular weight, composition ratios, and crosslinking density of the polymer components to achieve a balance between biocompatibility (low toxicity) and mechanical strength, ensuring the material is safe for in vivo use while providing sufficient durability
4Object-generated harmful factors
If the polymer composition has low thrombogenicity, then the material is resistant to blood clotting, but the biocompatibility may be compromised
Solution Approach 1:
The patent optimizes the surface properties, composition, and crosslinking density of the polymer to achieve low thrombogenicity (resistance to blood clotting) while maintaining high biocompatibility, ensuring the material is both safe for in vivo use and resistant to thrombus formation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition exhibits favorable handling properties, rapid curing without excessive heat, and maintains mechanical integrity for a prolonged period, effectively repairing aneurysms and preventing further vessel dilatation, with a cured material showing high resistance to abrasion and suitable for use as an arterial graft.
Implementation Method 1
said composition is curable in an aqueous environment at a temperature of 37°C to form a cured material
Implementation Method 2
a viscosity at 25°C, as measured by a Brookfield viscosimeter, UK, of 2 000-12 000 cSt
Data Source
AI summary
The present invention relates to a biocompatible polymer composition, suitable for in vivo vessel repair, comprising a matrix pre-polymer, a filler and a curing agent, wherein said composition wherein said biocompatible polymer composition is curable in the presence of a curing catalyst at 37° C. to form a cured material with an elongation until rupture of at least 5% and an elastic modulus of at least 1 MPa.