Polymeric Disinfectant Coatings for Low-Cytotoxic SARS-CoV-2 Inactivation
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Solution Overview
Problem
Existing disinfectants, as listed by the EPA, are not specifically tested against SARS-CoV-2 and may not be effective enough to inactivate the virus on various surfaces, while bleach-based disinfectants can be cytotoxic.
Innovation Solution
Development of polymers with bifunctional heterocyclic or heteroaromatic repeating units, functionalized with quaternary ammonium groups and N-halogen bonds, which continuously release hypohalogen ions to inactivate SARS-CoV-2 by attracting and damaging the virus.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If bleach-based disinfectants are used to inactivate SARS-CoV-2, then viral inactivation effectiveness is improved, but cytotoxicity increases
Solution Approach 1:
The invention changes the chemical parameters of the disinfectant by using polymers with quaternary ammonium groups and N-halogen bonds instead of bleach, achieving effective viral inactivation with reduced cytotoxicity
Solution Approach 2:
The invention uses composite polymer structures combining quaternary ammonium groups and N-halogen bonds in a single molecular framework, creating a multifunctional disinfectant that achieves both effectiveness and safety
2Adaptability or versatility
If existing EPA-approved disinfectants are used, then broad spectrum coverage is achieved, but effectiveness against SARS-CoV-2 is insufficient
Solution Approach 1:
The polymer disinfectant is designed with multiple functional groups (quaternary ammonium and N-halogen bonds) that provide both broad-spectrum antimicrobial activity and specific effectiveness against SARS-CoV-2
3Reliability
If higher concentrations of disinfectant are used to achieve better viral inactivation, then antiviral activity is improved, but cytotoxicity increases
Solution Approach 1:
The invention optimizes the concentration parameters by achieving effective antiviral activity at lower concentrations through the synergistic action of quaternary ammonium groups and N-halogen bonds, thereby reducing cytotoxicity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polymers exhibit superior antiviral activity, achieving 99.9% reduction of SARS-CoV-2 spikes at lower concentrations than bleach and maintaining efficacy on various surfaces for a week, with no cytotoxicity, thus providing a safer and more effective disinfection solution.
Implementation Method 1
The polymers exhibit superior antiviral activity, achieving 99.9% reduction of SARS-CoV-2 spikes at lower concentrations than bleach
Implementation Method 2
functionalized with quaternary ammonium groups and N-halogen bonds, which continuously release hypohalogen ions to inactivate SARS-CoV-2 by attracting and damaging the virus
Data Source
AI summary
Polymers including bifunctional mono- or poly-cyclic heterocyclic or heteroaromatic repeating units having disinfecting activity, compositions thereof, and methods for disinfecting surfaces utilizing the compositions. The method for disinfecting includes brushing, spraying, wiping, casting, dipping, or vapor coating, to the surface a disinfecting material to thereby render the surface antiseptic. The surface being disinfected by this method may be smooth, rough, tough, or soft, and may be selected from a cardboard, cloth, stainless steel or metallic surface, plastic, glass, wood, paper, surgical glove, or skin.