Polymeric Cutting Device for Biologic Tissue Disruption
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Solution Overview
Problem
Existing devices for disrupting biologic materials often release metallic residuals during the process, which can contaminate the resulting cell suspensions and clusters, making them unsuitable for medical and surgical applications.
Innovation Solution
A device featuring a flexible, polymeric cutting element with micro-openings and micro-blades, made from TRIREX 3020IR plastic, which minimizes damage to cell membranes and eliminates the risk of metallic residuals by using a holed disk and a rotating vane to delicately disrupt tissues, with a capillary channel for liquid management and a propeller for cleaning.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a metallic disruption grid with punched microholes is used, then the disruption of biologic material can be achieved, but metallic residuals are released in the disrupted suspension
Solution Approach 1:
The invention extracts and removes the metallic disruption grid from the system, replacing it with a polymeric alternative. This eliminates the source of metallic residuals while preserving the disruption function through the polymeric disk with microholes and micro-blades
Solution Approach 2:
The invention changes the material parameter of the disruption grid from metallic to polymeric (specifically medical-grade polyethylene or similar biocompatible polymers). This material substitution eliminates metallic residual release while maintaining the structural functionality for tissue disruption
2Productivity
If aggressive cutting methods are used to disrupt solid biologic material, then disruption efficiency is improved, but cell membranes are damaged
Solution Approach 1:
The invention applies local quality by creating micro-blades at the edges of microholes in the polymeric disk. These localized cutting elements provide sufficient disruption capability while the overall gentle polymeric structure prevents excessive damage to cell membranes, achieving a balance between disruption efficiency and cell integrity
Solution Approach 2:
The invention changes the physical parameter of the cutting element from rigid metallic to flexible polymeric. This parameter change allows the material to cut effectively through tissue while being gentler on cell structures, preventing membrane damage while maintaining disruption efficiency
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively produces cell suspensions and clusters without metallic residuals, ensuring the integrity of cell membranes and enabling safe use in medical and surgical applications for wound healing.
Implementation Method 1
at least one cutting element (6), a flexible holed polymeric disk (6) cutting on the edges of the holes
Implementation Method 2
a propeller for cleaning
Implementation Method 3
at least one capillary channel (68) with connection of the Luer syringe type, connected to the collecting chamber (14) and configured for respectively entering and withdrawing the liquid for the dissociation and the liquid with biologic material in suspension
Data Source
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AI summary
A disrupting and dissociating device (1) of solid biologic materials is described, comprising: a case (2) defining at least one internal chamber (4); at least one cutting element (6), made of polymeric material, housed inside said chamber (4) in order to define a loading chamber (12) of biologic substances to be disrupted and a collecting chamber (14) of disrupted biological substances; at least one vane (20) configured to take the biologic substances in contact with the cutting element (6) and, cooperating with the cutting element (6), allow the disruption and the passage from the loading chamber (12) to the collecting chamber (14) of the disrupted biological substances, being at least one between the cutting element (6) and the mobile vane (20) with respect to the other.