Polymethoxyflavone Sweetness Enhancers for Prolonged Flavor Release

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Solution Overview

Problem

There is a need for sweeteners that provide high-intensity sweetness without caloric content, have a prolonged release rate, and enhance flavor sensations, while avoiding unpleasant off-flavors and rapid release rates found in conventional sweeteners.

Innovation Solution

Compositions comprising hexamethoxyquercetogenin (3,5,6,7,3',4'-hexamethoxyflavone) and tetra-O-methylscutellarein are used as sweeteners or sweetness enhancers, providing enhanced sweetness and prolonged release when added to consumable products at concentrations ranging from 0.001 to 20 ppm, often at 2 ppm, and can include additional sweeteners.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of moving object

If conventional sweeteners are used, then high sweetness intensity is achieved, but the release rate is rapid and sweetness is lost quickly

Engineering Contradiction:
Improveduration of sweetness releaseVSAvoidrelease rate of sweetener
Core Design Contradiction:
Duration of action of moving objectVSProductivity

Solution Approach 1:

The patent changes the chemical structure parameters of sweeteners by using polymethoxyflavones with specific methoxyl group substitutions. This structural modification alters the release kinetics and prolongs sweetness duration while maintaining high intensity, directly resolving the contradiction between rapid release and prolonged action.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs composite sweetener formulations combining polymethoxyflavones with other sweetening agents or carriers. This composite approach enables controlled release mechanisms that extend sweetness duration while preserving high intensity, addressing the contradiction between rapid release and prolonged sensation.

Inventive Principle:
Principle #40Composite materials

2Quantity of substance

If non-caloric high-intensity sweeteners are used, then sweetness is enhanced, but unpleasant off-flavors are introduced

Engineering Contradiction:
Improvesweetness intensityVSAvoidoff-flavors
Core Design Contradiction:
Quantity of substanceVSObject-generated harmful factors

Solution Approach 1:

The patent modifies molecular parameters of sweeteners through polymethoxyflavone structures with controlled methoxyl group positions and numbers. This parameter optimization enhances sweetness intensity while eliminating the unpleasant off-flavors typically associated with non-caloric sweeteners, resolving the contradiction between intensity and flavor quality.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent converts the potential harm of off-flavors into benefit by using methoxyl group substitutions that naturally suppress unpleasant tastes. The methoxyl groups act as flavor-modifying moieties that transform potentially harmful off-flavors into desirable sweet taste profiles, maintaining high intensity without unpleasant notes.

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

3Duration of action of moving object

If sweetness enhancers are added to consumable products, then prolonged sweet sensation is achieved, but the product requires additional components

Engineering Contradiction:
Improveduration of sweet sensationVSAvoidcomplexity of sweetener composition
Core Design Contradiction:
Duration of action of moving objectVSDevice complexity

Solution Approach 1:

The patent creates polymethoxyflavone compounds that simultaneously provide multiple functions: high-intensity sweetening, prolonged release, and off-flavor suppression. This multi-functionality eliminates the need for separate enhancer components, achieving prolonged sensation without increasing formulation complexity.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent merges multiple desirable properties into a single polymethoxyflavone molecule: sweetness intensity, prolonged release kinetics, and flavor quality. By combining these functions in one compound rather than using separate sweetener and enhancer components, the patent achieves prolonged sensation without adding compositional complexity.

Inventive Principle:
Principle #5Merging (Combining)

Data Source

PatentEP3758509B1Polymethoxyflavones as sweetness enhancers
Publication Date: 2026.03.25 FIRMENICH SA
  • EP3758509B1 patent drawingFigure 1
  • EP3758509B1 patent drawing
  • EP3758509B1 patent drawing

AI summary

The present disclosure provides compositions that include tetra-O-methylscutellarein, hexamethoxyquercetagetin, or mixtures or combinations thereof, as well as their use as sweeteners or sweetness enhancers.