Bacteriostatic Agent Formulation Using Polyol and Dispersing Agent
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing biocidal formulations face challenges in maintaining stability and preventing microbial contamination without using toxic preservatives, while ensuring the viability and biocidal activity of microorganisms over time, especially in aqueous solutions.
Innovation Solution
Aqueous solutions containing a polyol and a dispersing agent with a polyol/dispersing agent ratio between 30:1 and 110:1, using sodium polycarboxylate or condensed naphthalene sulfonate as dispersing agents, which provide physical stability and high viscosity, preventing precipitation and microbial contamination, and maintaining microorganism viability for extended periods.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If dispersing agents are used to ensure stability of suspensions, then suspension stability is improved, but microorganism viability deteriorates
Solution Approach 1:
The invention changes the concentration parameters by specifying a polyol/dispersing agent ratio between 30:1 and 110:1 (weight/weight), with polyol at 5-95% w/w and dispersing agent at 0.5-5% w/w. This optimized parameter range resolves the contradiction by finding the balance point where sufficient dispersing agent is present for stability while polyol concentration is high enough to protect microorganism viability.
Solution Approach 2:
The invention uses a composite system combining polyol (glycerine, sorbitol, or monopropylene glycol) with specific dispersing agents (sodium polycarboxylate or condensed naphthalene sulfonate). This composite approach allows the polyol to protect microorganism viability while the dispersing agent ensures suspension stability, resolving the contradiction through synergistic material combination.
2Stability of the object's composition
If water content is increased to assure proper homogenization of suspensions, then homogeneity is improved, but microbial contamination accelerates
Solution Approach 1:
The invention optimizes water content to 40-50% w/w of the biocidal formulation, balancing homogenization needs with microbial contamination prevention. This specific parameter range ensures sufficient water for proper suspension homogenization while limiting excess water that would accelerate microbial growth.
Solution Approach 2:
The polyol acts as an intermediary substance that reduces the need for excessive water in the formulation. By providing viscosity and homogenization properties, the polyol allows lower water content (40-50% w/w) to achieve proper mixing while preventing the microbial contamination that would occur with higher water content.
3Object-affected harmful factors
If water content is decreased to prevent microbial contamination, then microbial contamination is reduced, but precipitation of excipients occurs
Solution Approach 1:
The invention optimizes water content to 40-50% w/w, which is sufficient to prevent precipitation of excipients and carriers while limiting microbial contamination. This balanced parameter prevents both extremes: too much water causing contamination and too little water causing precipitation.
Solution Approach 2:
The polyol serves as an intermediary that maintains suspension stability at reduced water levels. It provides the necessary viscosity and solvation properties to prevent precipitation of excipients while allowing lower water content (40-50% w/w) that limits microbial contamination.
4Object-affected harmful factors
If toxic preservatives are used to prevent microbial contamination, then microbial contamination is prevented, but environmental friendliness deteriorates
Solution Approach 1:
The invention extracts and eliminates toxic preservatives (parabens, azides, isothiazolines) from the formulation. Instead, it uses a polyol/dispersing agent system where polyol at 5-95% w/w provides the bacteriostatic effect, achieving microbial contamination prevention without toxic substances.
Solution Approach 2:
The invention replaces long-term toxic preservatives with a natural, biodegradable polyol system (glycerine, sorbitol, or monopropylene glycol). These polyols provide bacteriostatic activity through their chemical properties and are environmentally friendly, resolving the contradiction between effectiveness and environmental friendliness.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution ensures the stability and biocidal activity of bacterial suspensions, such as Bacillus subtilis, and protein-based formulations, like cystatins, maintaining effectiveness against pathogens like Sclerotinia, Botrytis, and Tetranychus urticae, comparable to chemical fungicides, without the need for toxic preservatives.
Implementation Method 1
aqueous solutions must contain bacteriostatic agents or preservatives to prevent microbial contamination
Implementation Method 2
dispersing agents assuring stability of the suspensions
Implementation Method 3
a low water concentration does not assure proper homogenization of the suspensions
Data Source
AI summary
The present invention relates to a bacteriostatic agent and biocidal formulations, describing a preservative-free bacteriostatic agent containing an aqueous solution of a polyol and a dispersing agent. The polyol/dispersing agent ratio is comprised between 30:1 (weight/weight) and 110:1 (weight/weight). The bacteriostatic agent is used as a diluent in environmentally-friendly biocidal formulations.