Treatment and prevention of infections using vegetable oil-derived polyols

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Solution Overview

Problem

Existing technologies have not effectively utilized vegetable oil-derived polyols as broad-spectrum antiviral and antibacterial agents, despite their potential in synthesizing various macromolecular compounds.

Innovation Solution

Vegetable oil-derived polyols, particularly linseed oil-derived polyols, are formulated into pharmaceutical compositions to target and inhibit viral and bacterial infections by binding to specific sites on pathogens, such as the CD4 binding site of HIV envelope glycoprotein gp120 and the SARS-CoV-2 spike protein, and interfering with sugar alcohol metabolism of bacteria like Streptomyces and Staphylococcus species.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If vegetable oil-derived polyols are used as therapeutic agents against viral infections, then antiviral efficacy is improved, but this application has not been previously established despite their known use as tensioactive agents and organogelators

Engineering Contradiction:

Improveantiviral efficacyVSAvoidtherapeutic application range

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent applies universality by demonstrating that vegetable oil-derived polyols serve multiple functions: they act as tensioactive agents, organogelators, corrosion inhibitors, and now also as broad-spectrum antiviral and antibacterial therapeutic agents. This multi-functionality resolves the contradiction by expanding the therapeutic application range while maintaining reliability through established biochemical mechanisms.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent utilizes parameter changes by modifying the functional properties of vegetable oil-derived polyols through chemical derivatization and formulation optimization. By adjusting molecular structure parameters and formulation conditions, the polyols achieve enhanced antiviral efficacy while maintaining their biodegradability and low cost advantages.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If vegetable oil-derived polyols are formulated into pharmaceutical compositions for broad-spectrum antiviral and antibacterial treatment, then therapeutic effectiveness is improved, but the complexity of formulation and administration increases

Engineering Contradiction:

Improvetherapeutic effectivenessVSAvoidformulation complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies self-service by utilizing the inherent properties of vegetable oil-derived polyols themselves as the therapeutic active ingredients, rather than requiring complex delivery systems. The polyols' natural biodegradability, low cost, and direct antiviral/antibacterial activity allow them to serve as self-contained therapeutic agents, simplifying formulation while maintaining effectiveness.

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The patent employs parameter changes by optimizing formulation parameters such as concentration, purity, and molecular structure to enhance therapeutic effectiveness without significantly increasing formulation complexity. The focus remains on the polyol's inherent properties rather than complex delivery mechanisms.

Inventive Principle:

Principle #35Parameter changes

3Ease of manufacture

If vegetable oil-derived polyols are used as therapeutic agents, then cost and biodegradability are improved, but specific polyols have not been previously established as broad-spectrum antiviral agents

Engineering Contradiction:

Improveproduction costVSAvoidantiviral activity

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

The patent applies the principle of using cost-effective, readily available vegetable oil-derived polyols as therapeutic agents. These polyols are produced from abundant natural resources at low cost and are biodegradable, making them economically viable and environmentally friendly therapeutic options that do not require expensive synthetic alternatives.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent utilizes parameter changes by optimizing the molecular structure and purity parameters of vegetable oil-derived polyols to enhance their antiviral activity. Through controlled synthesis and purification processes, the polyols achieve sufficient reliability as therapeutic agents while maintaining their cost-effectiveness and biodegradability advantages.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The polyols demonstrate high efficacy in inhibiting viral and bacterial infections, offering broad applicability, sustainability, low cost, and biodegradability, with the potential for synergistic effects when combined with other therapeutic agents.

Implementation Method 1

binding to specific sites on pathogens, such as the CD4 binding site of HIV envelope glycoprotein gp120

Methodology Applied

Scientific EffectMolecular binding:

Implementation Method 2

binding to specific sites on pathogens, such as... the SARS-CoV-2 spike protein

Methodology Applied

Scientific EffectMolecular binding:

Implementation Method 3

interfering with sugar alcohol metabolism of bacteria like Streptomyces and Staphylococcus species

Methodology Applied

Scientific EffectMetabolic interference:

Data Source

PatentUS20260007628A1Treatment and prevention of infections using vegetable oil-derived polyols

Publication Date: 2026.01.08 FLORIDA INTERNATIONAL UNIVERSITY

AI summary

The present invention is directed to a method of treatment or prevention of viral and/or bacterial infection comprising the administration of a polyol derived from a vegetable oil or its derivative. The vegetable oil is preferably linseed oil. The invention is also directed to a formulation comprising a vegetable oil-derived polyol.