Polyol-Based Topical Composition for Mucous Membrane Irritation
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Solution Overview
Problem
Topical products often cause irritation to the skin and mucous membranes due to ingredients like preservatives, detergents, and drugs, leading to inflammation and discomfort, and existing solutions are inadequate in addressing these issues, especially for sensitive skin types.
Innovation Solution
A topical composition combining polyols such as xylitol, myoinositol, or mannitol with glycerol and/or urea, along with a surface active agent, is used to create a non-irritant formulation that prevents and treats irritation caused by preservatives, detergents, or drugs, without oil-in-water or wax-in-water emulsions, and is specifically designed for mucous membranes like the eyes, nose, and vagina.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If topical products containing preservatives, detergents, or drugs are applied to skin or mucous membranes, then therapeutic or cosmetic effects are achieved, but irritation and cell damage occur
Solution Approach 1:
The patent introduces polyols (xylitol, myoinositol, mannitol) as intermediary substances that mediate between the irritating topical products and the mucous membrane cells. These polyols act as protective agents that reduce cell damage caused by preservatives, detergents, and drugs while allowing the therapeutic effects to persist. The polyols create a protective environment that enables safe application of necessary medicinal ingredients.
Solution Approach 2:
The patent changes the chemical composition parameters of topical formulations by incorporating specific concentrations of polyols (0.1%-10% w/v), glycerol (0.05%-5% w/v), and urea (0.05%-5% w/v). These parameter changes transform the formulation from irritating to non-irritating while maintaining therapeutic efficacy. The patent specifically identifies optimal concentration ranges that balance protection against irritation with preservation of drug effectiveness.
2Adaptability or versatility
If conventional topical formulations are used, then treatment coverage is achieved, but sensitive skin types experience increased irritation and discomfort
Solution Approach 1:
The patent creates a universal formulation system that functions across multiple application types (eye drops, nasal sprays, vaginal treatments, skin creams) and serves multiple purposes simultaneously: delivering therapeutic drugs, protecting sensitive skin, and preventing irritation. The polyol-based protective system is universally applicable to various mucous membranes and skin types, making the formulation adaptable to different patient needs while consistently reducing irritation.
3Object-affected harmful factors
If existing anti-irritation solutions are applied, then some relief is provided, but they are inadequate for treating severe irritation and cell damage
Solution Approach 1:
The patent employs composite formulations combining multiple protective agents (polyols, glycerol, urea) with therapeutic drugs. This composite approach creates a synergistic system where each component contributes to irritation reduction and cell protection. The combination of xylitol/myoinositol/mannitol with glycerol and urea provides enhanced protective effects compared to single agents, reliably treating severe irritation and cell damage that conventional solutions cannot address.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces irritation and cell damage, providing a synergistic effect that enhances moisture and viscosity, improving the treatment of mucous tissues and skin cells, as demonstrated by increased Break Up Time in dry eye patients and significant improvement in symptoms of dry nose syndrome.
Implementation Method 1
A topical composition combining polyols such as xylitol, myoinositol, or mannitol with glycerol and/or urea... providing a synergistic effect that enhances moisture and viscosity
Implementation Method 2
A topical composition combining polyols such as xylitol, myoinositol, or mannitol with glycerol and/or urea, along with a surface active agent
Data Source
AI summary
A topical pharmaceutical or cosmetic composition for treatment of irritation of mucous cells such as mucosal cells of the eye, nose, and vagina is disclosed. The composition comprises an aqueous solution of at least one polyol selected from the group consisting of xylitol, myoinositol and mannitol and at least one substance selected from the group consisting of glycerol and urea. The composition contains less than 0.01% inorganic salt and is free of any oil-in-water or wax-in-water emulsion. In particularly preferred embodiments, the composition comprises an aqueous solution containing 1.5-5% (w/v) xylitol and 0.9-2.0% (w/v) glycerol.