Polypeptide Topical Compositions for UV Damage and Skin Aging
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Solution Overview
Problem
Current skincare products lack effective solutions for treating and preventing skin conditions such as skin aging, UV-induced damage, and wound healing, with a significant economic burden on healthcare systems and reduced quality of life for affected individuals.
Innovation Solution
The use of specific polypeptides, including RSKAKNPLY, RRRRRRRRR, and their dextro-reverso forms, which can be formulated into topical compositions to inhibit DNA damage, promote wound healing, and reduce skin aging by increasing ATP levels and reducing oxidative stress.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If UV radiation is used for skin treatment, then skin conditions can be addressed, but DNA damage and oxidative stress increase
Solution Approach 1:
The patent converts the harmful effects of UV radiation (DNA damage, oxidative stress) into beneficial outcomes by using the same UV-exposed skin context to demonstrate the protective and reparative effects of the polypeptide compositions. The compositions mitigate UV-induced damage while allowing controlled UV exposure for therapeutic purposes.
Solution Approach 2:
The polypeptide compositions act as intermediary substances between UV radiation and skin cells, reducing the direct harmful impact of UV on DNA while maintaining the therapeutic benefits of UV exposure for skin condition treatment.
2Object-affected harmful factors
If DNA repair enzymes are applied to reduce DNA damage, then skin cancer risk decreases, but treatment complexity and cost increase
Solution Approach 1:
The patent changes the parameter of the active ingredient from complex DNA repair enzymes to simpler polypeptide sequences (such as polyarginine and specific amino acid sequences) that achieve similar protective effects through different mechanisms, including ATP enhancement and oxidative stress reduction.
Solution Approach 2:
The polypeptide compositions provide a cost-effective alternative to expensive DNA repair enzyme treatments, using simpler, shorter-lived polypeptide molecules that can be easily synthesized and applied topically.
3Productivity
If ATP production is increased to repair photo-damaged DNA, then DNA repair efficacy improves, but energy stress on cells increases
Solution Approach 1:
The polypeptide compositions perform preliminary actions by enhancing ATP production and reducing oxidative stress before significant DNA damage occurs, preparing the cellular energy state for efficient DNA repair without causing excessive energy stress.
Solution Approach 2:
The compositions maintain continuous protective action by sustainably enhancing ATP levels and reducing oxidative stress over time, allowing DNA repair to proceed continuously without periodic energy stress spikes.
Data Source
AI summary
The present disclosure relates to polypeptides, compositions and methods for preventing and/or treating skin conditions including dermal aging and skin conditions associated with UV and/or high energy visible light exposure.