Polyphenol-Crosslinked Collagen Gel for Bone Defect Filling
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Solution Overview
Problem
Current dental filler materials for bone resorption diseases lack anti-inflammatory and antioxidant effects, which are essential for controlling osteoclastogenesis and oxidative stress-induced tissue damage, despite providing mechanical and biological stimulation for bone regeneration.
Innovation Solution
A composition combining hydroalcoholic extracts of polyphenols from grape seeds and skins with collagen and pectin, cross-linked to form a stable gel that provides anti-inflammatory and antioxidant actions, combined with ceramic granules for mechanical support, creating a malleable filler material suitable for bone defects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional filler materials (bovine bone, phosphate-ceramics, collagen) are used to provide mechanical support and biological stimulation for bone regeneration, then bone regeneration is promoted through osteoconduction and osteoinduction, but anti-inflammatory and antioxidant effects are lacking, leading to uncontrolled osteoclastogenesis and oxidative stress-induced tissue damage
Solution Approach 1:
The invention combines multiple materials into a composite filler composition including ceramic granules (hydroxyapatite, beta-tricalcium phosphate) for mechanical support, collagen gel for biological stimulation, and polyphenolic extracts (procyanidins, proanthocyanidins) for anti-inflammatory and antioxidant protection. This composite approach integrates osteoconduction, osteoinduction, and tissue protection functions into a single formulation.
Solution Approach 2:
The invention merges three distinct functional components into one unified filler material: (1) ceramic granules providing structural scaffold, (2) collagen gel providing biological activity and gel structure, and (3) polyphenolic extracts providing antioxidant and anti-inflammatory protection. The components are combined in a synergistic formulation where each component addresses specific aspects of bone regeneration and tissue protection.
2Object-affected harmful factors
If polyphenolic extracts are added to provide anti-inflammatory and antioxidant effects, then osteoclastogenesis and oxidative stress are reduced, but the stability and longevity of antioxidant activity may be limited due to the natural degradation of polyphenols
Solution Approach 1:
The collagen gel acts as an intermediary carrier that encapsulates and protects polyphenolic extracts, enabling their controlled release over time. The gel matrix slows down the degradation and release of polyphenols, extending their protective activity from hours to days or weeks, while maintaining their bioactivity at the defect site.
Solution Approach 2:
The invention changes the physical state and release kinetics of polyphenolic extracts by incorporating them into a collagen gel matrix. This transforms the polyphenols from a rapidly degrading free solution into a controlled-release system, modifying the temporal profile of their antioxidant and anti-inflammatory activity to match the needs of bone regeneration.
3Strength
If a rigid ceramic filler is used to provide mechanical support, then structural integrity is maintained, but adaptability to the defect cavity and ease of application are reduced
Solution Approach 1:
The invention uses a collagen gel matrix that provides flexibility and moldability, allowing the filler to be easily adapted to irregular defect cavities. The gel can be injected or packed into the defect space and will conform to the cavity shape, while the embedded ceramic granules provide the necessary mechanical strength and structural support once the gel sets.
Solution Approach 2:
The composite structure combines rigid ceramic granules for mechanical strength with a flexible collagen gel matrix for adaptability. This allows the filler to simultaneously provide structural support and ease of application, as the gel component can be easily manipulated and adapted to the defect geometry while the ceramic component ensures mechanical integrity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces osteoclastogenesis and oxidative stress, maintaining antioxidant activity over a prolonged period, enhancing bone regeneration and tissue protection while maintaining mechanical support and bio-stimulating properties.
Implementation Method 1
a collagen gel cross-linked with polyphenols in a ceramic support matrix
Implementation Method 2
The composition effectively reduces osteoclastogenesis and oxidative stress, maintaining antioxidant activity over a prolonged period
Implementation Method 3
The composition effectively reduces osteoclastogenesis and oxidative stress, maintaining antioxidant activity over a prolonged period
Implementation Method 4
providing a functional scaffold for cell adhesion (osteoconduction) and subsequent bone regeneration
Implementation Method 5
combining a synthetic ceramic filler or natural bone... so as to obtain a malleable gel easy to adapt to the cavity
Data Source
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AI summary
The present invention relates to a composition for filling tissue defects, such as defects due to loss of soft tissue or resorption of bone tissue around natural teeth (periodontal defects) or implant screws (peri-implant defects), to increase the size of the alveolar ridge, to fill extraction sites and to raise the maxillary sinus. In particular, the present invention relates to a filler material for dental use, said material comprising a collagen gel cross-linked with polyphenols in a ceramic support matrix.