Polyphenol Composition for Companion Animal Eye Health

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Solution Overview

Problem

Companion animals face vision loss due to free radical damage from environmental stress, aging, and blue light exposure, leading to cataract formation and impaired vision, with existing solutions failing to effectively prevent or treat these issues.

Innovation Solution

A composition comprising polyphenols such as rosemary extract, coffee extract, turmeric extract, blueberry extract, grapeseed extract, and tea extract, which act as antioxidants to prevent photo-oxidative stress and inflammation, thereby promoting eye health and slowing down cataract progression.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If light is used to enable vision, then vision ability is improved, but free radical production increases causing cell and membrane damage

Engineering Contradiction:
Improvevision abilityVSAvoidfree radical production
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent applies this principle by using antioxidants to convert the harmful effect of light-induced free radicals into a beneficial outcome. The antioxidants neutralize the free radicals produced during vision, transforming the damaging effect into a protected state where vision function is maintained without cellular damage to the lens and corneal epithelial cells.

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

2Use of energy by moving object

If blue light exposure occurs, then tissue penetration and photoreceptor stimulation are improved, but photochemical damage and apoptotic cell death increase

Engineering Contradiction:
Improvephotoreceptor stimulationVSAvoidphotochemical damage
Core Design Contradiction:
Use of energy by moving objectVSObject-affected harmful factors

Solution Approach 1:

The patent applies this principle by introducing antioxidants as intermediary substances that mediate between blue light exposure and photoreceptor cells. These antioxidants act as protective intermediaries that absorb or neutralize the harmful photochemical effects of blue light while allowing beneficial photoreceptor stimulation to occur, thereby protecting retinal epithelial cells from damage.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Duration of action of stationary object

If aging occurs, then life span is extended, but free radical stress increases leading to cataract formation

Engineering Contradiction:
Improvelife spanVSAvoidfree radical stress
Core Design Contradiction:
Duration of action of stationary objectVSObject-generated harmful factors

Solution Approach 1:

The patent applies this principle by administering antioxidants in advance to prevent free radical damage before it occurs. By providing antioxidants proactively during the aging process, the composition prevents the accumulation of free radical stress that would otherwise lead to cataract formation, allowing the animal to maintain eye health throughout an extended lifespan.

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively reduces free radical damage, improves vision, and maintains younger eyes by inhibiting oxidative stress and inflammation, providing a comprehensive solution for environmental and age-related eye health issues in companion animals.

Implementation Method 1

The present invention relates to a composition for promoting eye health in a companion animal comprising: at least one polyphenol selected from the group consisting of rosemary extract, rosemarinic acid, coffeic acid, coffee extract, turmeric extract, cucurmin, blueberry extract, grapeseed extract, rosemarinic acid, tea extract, and mixtures thereof.

Methodology Applied
Scientific EffectAntioxidant activity: Oxidation

Implementation Method 2

Exposure to visible blue light causes an increase in both mitochondrial and nuclear DNA lesions and an increase in free radical production in retinal epithelial cells.

Methodology Applied
Scientific EffectOxidative stress inhibition: Oxidation

Data Source

PatentEP2023945B1Composition for improving eye health
Publication Date: 2019.08.07 IAMS EURO BV
  • EP2023945B1 patent drawing

AI summary

The present invention relates to a composition for promoting eye health in a companion animal. The composition comprising: at least one polyphenol selected from the group consisting of rosemary, rosemary extract, coffee acid, coffee extract, turmeric extract, cucurmin, blueberry extract, grapeseed extract, rosemarinic acid, tea extract, and mixtures thereof.