Biodegradable Polyphosphazenes with Pyrrolidone Side Groups

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Solution Overview

Problem

Current polyphosphazene polymers lack effective biodegradability and biocompatibility for medical applications, leading to potential accumulation in the body and adverse reactions.

Innovation Solution

Development of polyphosphazene polymers with N-alkyl pyrrolidone side groups, produced by reacting poly(dichlorophosphazene) with organic nucleophiles, which are biodegradable and biocompatible, allowing for controlled release of pharmaceuticals and use as coatings for medical devices.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If polyphosphazene polymers are used for medical applications, then pharmaceutical release and device coating functions are provided, but biodegradability is insufficient leading to accumulation in the body

Engineering Contradiction:

ImprovebiocompatibilityVSAvoidbiodegradation time

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent modifies the chemical structure of polyphosphazene by introducing specific side groups (carboxyl, hydroxyl, amino groups) and controlling molecular weight and stereochemistry to optimize the balance between biocompatibility and biodegradation rate, transforming the polymer from non-biodegradable to biodegradable within a controlled timeframe

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates composite polyphosphazene structures combining the phosphazene backbone with various functional side groups and stereochemical configurations, resulting in a material that integrates both biocompatibility and controlled biodegradability properties

Inventive Principle:

Principle #40Composite materials

2Reliability

If polyphosphazene polymers are used for medical applications, then pharmaceutical release and device coating functions are provided, but adverse reactions occur due to accumulation

Engineering Contradiction:

ImprovebiocompatibilityVSAvoidadverse reactions

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

By adjusting molecular weight, side group composition, and stereochemical structure, the patent optimizes the polymer's interaction with biological systems to minimize immune response and adverse reactions while maintaining therapeutic functionality

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent converts the previously harmful accumulation property into a beneficial controlled biodegradation process, where the polymer gradually breaks down into harmless byproducts (ammonia, carbon dioxide, water) that are naturally metabolized by the body

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The resulting polymers are biodegradable within a suitable timeframe, preventing accumulation and inducing minimal adverse reactions, while providing a controlled release mechanism for pharmaceuticals and biocompatible coatings for medical devices.

Implementation Method 1

produced by reacting poly(dichlorophosphazene) with organic nucleophiles

Methodology Applied

Scientific EffectNucleophilic substitution: Chemical Bonding

Implementation Method 2

The resulting polymers are biodegradable within a suitable timeframe

Methodology Applied

Scientific EffectHydrolysis: Hydrolysis

Data Source

PatentUS10076573B2Biodegradable polyphosphazenes containing pyrrolidone side groups

Publication Date: 2018.09.18 INNOVO BIOPOLYMERS LLC

AI summary

Biodegradable polyphosphazene polymers containing pyrrolidone side groups, and the biomedical use of such polyphosphazene polymers are disclosed.