Polysaccharide Coating Balloon Catheter Drug Adhesion
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Solution Overview
Problem
Existing drug-coated balloons face challenges with the adherence and long-term retention of medical substances on the vessel wall, leading to inadequate drug delivery and increased risk of restenosis due to rapid drug release and washaway by the bloodstream.
Innovation Solution
A method involving a polysaccharide coating on the balloon catheter, where the surface is first treated with a polysaccharide solution followed by an active substance solution, enhancing adhesion and prolonged retention of the active ingredient on the vessel wall, allowing for rapid transfer and sustained release during balloon expansion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If the balloon surface is coated with an active agent dissolved in a solvent, then the active agent can be applied to the balloon surface, but the adherence of the active agent on the balloon becomes problematic
Solution Approach 1:
The patent introduces a polysaccharide coating as an intermediary layer between the balloon surface and the active agent. This mediator layer improves the adherence of the active agent to the balloon surface, solving the problem of poor adherence while maintaining effective drug delivery. The polysaccharide layer acts as a binding interface that enhances the retention of the active agent during balloon expansion and catheter withdrawal.
2Reliability
If the balloon is expanded for a short time (30-60 seconds), then ischemic conditions are avoided, but the transfer of active ingredient may not be sufficient
Solution Approach 1:
The patent modifies the physical and chemical parameters of the coating system by using a polysaccharide-based coating matrix. This changes the release kinetics of the active ingredient, enabling sustained release over the brief balloon expansion period (30-60 seconds). The polysaccharide matrix controls the diffusion rate of the active agent, ensuring sufficient transfer to the vessel wall within the limited time window while avoiding ischemic conditions.
3Speed
If the active agent is released rapidly from the balloon, then drug delivery is fast, but the drug is washed away by the bloodstream before achieving long-term effect
Solution Approach 1:
The patent employs a polysaccharide coating matrix with controlled porosity that enables rapid initial release of the active ingredient while maintaining sustained release capabilities. The porous structure allows quick diffusion of the drug to the vessel wall upon balloon expansion, while the polysaccharide matrix retains some drug reservoir that continues to release medication over an extended period, preventing complete washaway by the bloodstream and achieving both fast delivery and long-term effect.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polysaccharide coating improves the adherence and prolonged retention of the active ingredient on the vessel wall, ensuring effective and sustained drug delivery, with significant concentrations remaining for weeks after treatment, reducing the risk of restenosis.
Implementation Method 1
The polysaccharide coating improves the adherence and prolonged retention of the active ingredient on the vessel wall
Implementation Method 2
ensuring effective and sustained drug delivery, with significant concentrations remaining for weeks after treatment
Data Source
AI summary
The invention relates to a method for coating the balloon of a balloon catheter, wherein the surface of the balloon is wetted at least partially with a first solution containing a polysaccharide and the part of the surface of the balloon wetted with the first solution is wetted with a second solution containing an active agent. In this way, the balloon is provided with an active agent layer which is effectively applied to the inner wall of the vessel when the balloon is inflated and moreover results in a delayed long-lasting release of the active agent.