Polysaccharide Spherical Gel Resin Preparation Method

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Solution Overview

Problem

Existing methods for preparing polysaccharide gels result in small particle sizes with uneven distribution and amorphous structures, while achieving large, uniform, high-strength polysaccharide spherical gels remains a challenge.

Innovation Solution

A method involving the preparation of a polysaccharide mixed solution by heating a mixture of polysaccharides, solvents, and auxiliary agents, followed by forming spherical liquid drops and subjecting them to multi-stage temperature control and secondary crosslinking to achieve high-strength, uniformly sized polysaccharide spherical gels.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Volume of moving object

If conventional chemical crosslinking or physical crosslinking methods are used to prepare polysaccharide gels, then gel formation is achieved, but the particle size remains small (less than 1 mm) and particle size distribution is uneven

Engineering Contradiction:
Improveparticle sizeVSAvoidparticle size distribution
Core Design Contradiction:
Volume of moving objectVSManufacturing precision

Solution Approach 1:

The patent applies preliminary action by pre-forming spherical liquid drops with controlled sizes (4-15 mm) before the crosslinking process. The liquid drops are formed in a controlled manner using a liquid drop forming device, ensuring uniform initial sizes. This preliminary size control prevents the particle size distribution problems that occur when crosslinking is performed first and size control is attempted afterward.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent segments the preparation process into distinct stages: (1) forming spherical liquid drops with controlled sizes, (2) curing the drops to form gel spheres, and (3) performing crosslinking on the already-formed spheres. This segmentation allows each stage to be optimized independently, particularly enabling precise particle size control in the first stage without compromising the crosslinking quality in subsequent stages.

Inventive Principle:
Principle #1Segmentation

2Strength

If chemical crosslinking is used to form high-strength gels, then gel strength is improved, but the gel structure becomes irreversible and cannot undergo thermal transformation

Engineering Contradiction:
Improvegel strengthVSAvoidreversibility
Core Design Contradiction:
StrengthVSStability of the object's composition

Solution Approach 1:

The patent applies parameter changes by carefully controlling the crosslinking conditions, including using specific crosslinking agents (epoxy compounds), controlling crosslinking time (1-24 hours), temperature (20-50°C), and pH conditions (adding alkaline solution). These parameter optimizations enable achieving high gel strength while maintaining partial reversibility and elasticity, resolving the contradiction between strength and reversibility.

Inventive Principle:
Principle #35Parameter changes

3Productivity

If polysaccharide gels are prepared by existing methods, then gel formation is achieved, but the yield is low and environmental impact is high due to wastewater discharge

Engineering Contradiction:
ImproveyieldVSAvoidwastewater discharge
Core Design Contradiction:
ProductivityVSObject-generated harmful factors

Solution Approach 1:

The patent applies self-service by using natural polysaccharides (agar, agarose, carrageenan, pectin, gelatin, guar gum, chitosan, or sodium alginate) as raw materials that are biodegradable and environmentally friendly. The process generates minimal harmful wastewater compared to synthetic monomer-based gels. Additionally, the high yield (70-90%) is achieved through the efficient liquid drop forming and curing process, reducing material waste.

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method produces polysaccharide spherical gels with large sizes (4-15 mm), uniform particle distribution, high strength, and improved yield, while minimizing environmental impact through reduced wastewater discharge.

Implementation Method 1

forming spherical liquid drops and subjecting them to multi-stage temperature control and secondary crosslinking

Methodology Applied
Scientific EffectPhase change: Phase Change

Implementation Method 2

forming spherical liquid drops

Methodology Applied
Scientific EffectSurface tension: Surface Tension

Implementation Method 3

The chemical gels are formed by crosslinking with strong chemical bonds

Methodology Applied
Scientific EffectChemical crosslinking: Chemical Bonding

Implementation Method 4

Conventional high-molecular gels are generally polymerized by using water-soluble monomers

Methodology Applied
Scientific EffectPolymerization: Photopolymerisation

Implementation Method 5

adding a polysaccharide, a solvent and an auxiliary agent into a batching kettle at a certain ratio, performing heating to 85-95° C., and performing stirring until a clarified solution is obtained

Methodology Applied
Scientific EffectHeating: Heating

Implementation Method 6

cooling and curing

Methodology Applied
Scientific EffectCooling: Cooling

Implementation Method 7

The gels have many classification methods, and are usually classified according to sources, media, molecular composition

Methodology Applied
Scientific EffectGelation: Gel

Data Source

PatentUS12312447B2Preparation method for polysaccharide spherical gel resin
Publication Date: 2025.05.27 ZHEJIANG TRIPLE WIN MEDICAL APPLIANCE

AI summary

The present disclosure discloses a preparation method for polysaccharide spherical gel resin, and belongs to the technical field of compositions of high-molecular compounds. The preparation method includes: (1) adding a polysaccharide, a solvent and an auxiliary agent into a batching kettle at a ratio, performing heating to 85-95° C., and performing stirring until being clarified to obtain a polysaccharide mixed solution; (2) conveying the mixed solution to a drip tray, and performing heat preservation at 60-90° C.; (3) adding spherical liquid drops formed from the mixed solution by a liquid drop forming device into a forming tower to form polysaccharide spherical gels; (4) performing oil-sphere separation; (5) performing primary cleaning; (6) performing primary screening; (7) performing secondary crosslinking; and (8) performing secondary cleaning to obtain a final product. According to the present disclosure, the polysaccharide spherical gel resin has advantages of good sphericity, high strength, high yield, and good appearance.