Polysaccharide Modulates Immune Response Without Increasing Viscosity
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Solution Overview
Problem
Current solutions for enhancing natural defense against cold and flu rely heavily on medicaments, and there is a need for edible products or pharmaceutical compositions that can modulate the immune response using naturally occurring compounds without compromising the organoleptic or technical properties of food products.
Innovation Solution
A polysaccharide with a backbone comprising alternating rhamnogalacturonan-I cores and alpha(1,4)-linked polygalacturonic acid or oligogalacturonic acid cores, obtained from plants like Camellia sinensis, Daucus carota, Glycine max, Malus domestica, and Beta vulgaris, which has a molecular weight of at least 70 kDa and a specific molar ratio of galacturonyl acid to rhamnosyl residues, is incorporated into edible products or pharmaceutical compositions to stimulate immune response.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If polysaccharide is incorporated to modulate immune response, then immune stimulation is improved, but product viscosity may increase
Solution Approach 1:
The patent applies parameter changes by carefully controlling the molecular weight of the polysaccharide (at least 70 kDa) and the molar ratio of galacturonyl acid to rhamnosyl residues (0.5:1 to 2:1). These specific parameter ranges optimize the balance between immune stimulation capability and minimal impact on food product viscosity, allowing the polysaccharide to function effectively as an immunomodulator without significantly altering the organoleptic properties of the food matrix.
2Reliability
If polysaccharide with specific structure is used for immune modulation, then immune response is improved, but manufacturing complexity increases
Solution Approach 1:
The patent specifies precise compositional parameters (molar ratio of galacturonyl acid to rhamnosyl residues between 0.5:1 and 2:1, and molecular weight of at least 70 kDa) that define the active polysaccharide structure. By establishing these clear parameter ranges, the patent simplifies the manufacturing process quality control while ensuring the polysaccharide maintains its immune-modulating properties, avoiding the need for overly complex purification or synthesis procedures.
Data Source
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AI summary
Objective of the present invention is to provide polysaccharides which modulate immune response, and which can be used as ingredients in edible products or pharmaceutical compositions. The present invention provides such polysaccharides obtained from the species Camellia sinensis, which comprise a rhamnogalacturonan-I core, and wherein the molar ratio of galacturonyl acid residues to rhamnosyl residues in the backbone of the polysaccharide is close to 1:1. The present invention also provides edible products or pharmaceutical compositions containing such polysaccharides, in order to modulate immune response.