Polysaccharide Synergic Mixture for Mucous Membrane Adhesion
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Solution Overview
Problem
Polysaccharide gels used in cosmetic applications lack optimal adhesion and ease of application on mucous membranes due to their individual properties not fully meeting the requirements for oral and nasal applications, particularly in terms of adhesion and compliance with the complex anatomical structures and environmental conditions of the oral and nasal cavities.
Innovation Solution
A composition comprising a mixture of at least three polysaccharides from different classes (elastic, weak, viscoelastic, and viscous gels) is developed, specifically formulated to achieve enhanced viscoelastic and adhesive properties suitable for mucosal applications, with specific ratios and combinations of polysaccharides such as Sclerotium gum, Caesalpinia spinosa gum, Ceratonia siliqua gum, and Pectin, which are selected based on rheological and texture analysis to create a product with improved adhesion and compliance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If individual polysaccharides are used in cosmetic formulations, then the formulation is simple and cost-effective, but the adhesion and ease of application on mucous membranes are insufficient
Solution Approach 1:
The patent applies composite materials by combining multiple polysaccharides (xanthan gum, sclerotium gum, and gellan gum) into a synergistic mixture. Each polysaccharide contributes different rheological properties, and their combination creates a gel formulation with enhanced adhesion and viscoelasticity specifically optimized for mucous membrane applications, resolving the contradiction between formulation simplicity and adhesion reliability.
Solution Approach 2:
The patent utilizes parameter changes by adjusting the concentration ratios of different polysaccharides in the mixture. By optimizing the specific proportions of xanthan gum, sclerotium gum, and gellan gum, the formulation achieves optimal adhesion and ease of application parameters for mucous membranes while maintaining manufacturing feasibility.
2Reliability
If polysaccharide gels are formulated for mucosal application, then adhesion is improved, but the complexity of the formulation increases
Solution Approach 1:
The patent employs composite materials by creating a structured mixture of three specific polysaccharides with complementary properties. This composite approach achieves superior adhesion on mucous membranes through synergistic interactions while maintaining a relatively straightforward formulation process, thus managing the complexity trade-off.
Solution Approach 2:
The polysaccharide mixture serves multiple functions simultaneously: it provides adhesion to mucous membranes, ensures ease of application through optimal rheology, and maintains stability. This multi-functionality reduces the need for additional formulation components, thereby limiting the increase in formulation complexity while achieving reliable adhesion.
3Ease of operation
If a single polysaccharide is used, then the formulation is easy to apply, but it cannot provide optimal adhesion and protective film formation on mucous membranes
Solution Approach 1:
The patent applies composite materials by combining xanthan gum (providing viscosity and ease of application), sclerotium gum (enhancing adhesion), and gellan gum (forming protective films). The synergistic interaction of these polysaccharides maintains ease of application while significantly improving protective film formation and adhesion reliability on mucous membranes.
Solution Approach 2:
The patent applies local quality by assigning specific functional roles to each polysaccharide component based on its inherent properties. Xanthan gum primarily provides ease of application through its rheological characteristics, while sclerotium gum and gellan gum contribute to adhesion and protective film formation, respectively. This functional differentiation optimizes both ease of operation and reliability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polysaccharide mixture demonstrates improved adhesion and ease of application on mucous membranes, providing a protective film that resists flushing by saliva and maintains therapeutic effectiveness for viral and bacterial infections, with specific formulations optimized for oral and nasal use.
Implementation Method 1
The polysaccharide mixture demonstrates improved adhesion and ease of application on mucous membranes, providing a protective film that resists flushing by saliva
Implementation Method 2
A composition comprising a mixture of at least three polysaccharides from different classes (elastic, weak, viscoelastic, and viscous gels) is developed, specifically formulated to achieve enhanced viscoelastic and adhesive properties suitable for mucosal applications
Data Source
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AI summary
Mucosal composition containing a mixture comprising at least three polysaccharides belonging to at least two of the following classes 1, 2, 3 and 4, as classified in Table 1 below in combination with suitable excipients and/or diluents, in which said mixture has: a) at 1Hz: complex module G∗ comprised between 1 and 500 Pa and Tan δ comprised between 0.3 and 1 b) Adhesivity A- 0.08 - 5 N.mm and c) the relative polysaccharides are selected from Table 2 below This composition is ideal for application on mucous membranes, particularly oral or nasal, in terms of adhesion, ease of application and compliance and is particularly effective in preventing and treating viral and bacterial infections.