Dehydrothermally Crosslinked Polysaccharide Particles for Tissue Repair
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Solution Overview
Problem
Polysaccharide gel materials used for surgical repair and drug delivery often face challenges during rehydration, including poor physical properties and the risk of inadvertently aspirating large solid chunks, and external crosslinking agents can damage tissues or have uncontrollable residence times.
Innovation Solution
Development of free-flowing rehydratable particles of substantially collagen-free dehydrothermally crosslinked polysaccharides, such as carboxymethylcellulose (CMC) and blends with chitosan, which provide rapid rehydration, thixotropic behavior, high viscosity, and controllable biodegradation, along with antimicrobial and hemostatic properties, to form cohesive gels that can be safely applied and broken down without forming large solid chunks.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If polysaccharide gel materials are packaged in dry form and rehydrated prior to use, then storage stability is improved, but rehydration may produce poor physical properties and risk of large solid chunk aspiration
Solution Approach 1:
The polysaccharide particles are pre-crosslinked during manufacturing before packaging in dry form. This preliminary crosslinking action ensures that when the particles are rehydrated prior to use, they maintain proper physical properties and do not form large solid chunks, thus resolving the contradiction between storage stability and rehydration quality.
Solution Approach 2:
The patent controls the degree of crosslinking as a key parameter during particle fabrication. By optimizing crosslinking density and uniformity, the particles achieve both storage stability in dry form and proper gel formation upon rehydration, preventing the formation of large solid chunks while maintaining reliability.
2Strength
If in situ crosslinking is used to improve rehydrated gel physical properties, then gel strength is improved, but there is increased risk of overly crosslinked gel being dislocated as large solid chunks
Solution Approach 1:
Instead of performing crosslinking in situ during surgery, the patent applies crosslinking as a preliminary action during the manufacturing process. This allows precise control over crosslinking degree and uniformity, ensuring adequate gel strength while preventing excessive crosslinking that would cause large solid chunk formation and aspiration risk.
Solution Approach 2:
The patent replaces the mechanical/surgical crosslinking process with a chemical crosslinking process controlled during manufacturing. This substitution enables precise control over crosslinking parameters, achieving the desired balance between gel strength and prevention of large solid chunk formation.
3Stability of the object's composition
If external crosslinking agents are used, then gel formation is achieved, but tissue damage or uncontrollable residence times occur
Solution Approach 1:
The patent extracts and removes the need for external crosslinking agents by incorporating crosslinking functionality directly into the polysaccharide particles during manufacturing. This eliminates the harmful effects of external agents on tissue while maintaining gel formation capability through controlled internal crosslinking.
Solution Approach 2:
The polysaccharide particles are designed to self-crosslink during manufacturing, making the system self-sufficient without requiring external crosslinking agents. This self-service approach achieves gel formation while avoiding tissue damage and uncontrollable residence times associated with external agents.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables the formation of polysaccharide gels with improved physical properties, controlled biodegradation, and antimicrobial behavior, facilitating safe and effective tissue repair and healing by preventing premature biodegradation and minimizing the risk of aspiration or tissue damage.
Implementation Method 1
free-flowing rehydratable particles of substantially collagen-free dehydrothermally crosslinked polysaccharide
Implementation Method 2
thixotropic behavior when sprayed or injected
Implementation Method 3
rapid, clump-free rehydration
Data Source
AI summary
Tissue and other body structures may be protected using a dry, free-flowing, sterilized mixture of chitosan particles and oxidized polysaccharide particles in sealed packaging. The mixture may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.