Complex Polysaccharide Composition for Th1/Th2 Immune Balance

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Solution Overview

Problem

Current treatments for ovalbumin-induced immune stress and allergic reactions, such as those caused by ovalbumin in egg white, often result in side effects and have limited efficacy, while existing polysaccharides provide insufficient regulation of Th1/Th2 immune balance.

Innovation Solution

A complex polysaccharide composition is formulated from Agaricus Blazei Murill, seaweed, glycyrrhiza, and honeysuckle, with specific mass percentages and extraction processes, to regulate Th1/Th2 immune balance and inhibit ovalbumin-induced immune stress.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If chemical drugs (loratadine, cetirizine hydrochloride, calamine lotion, hydrocortisone cream) are used to antagonize allergic reactions, then immune stress response is suppressed, but side effects occur (thirst, headache, abnormal liver function, systemic anaphylaxis)

Engineering Contradiction:

Improveimmune stress responseVSAvoidside effects

Core Design Contradiction:

Object-affected harmful factorsVSObject-generated harmful factors

Solution Approach 1:

The patent introduces plant polysaccharides as an intermediary substance that mediates immune regulation differently from chemical drugs. These polysaccharides from sources like lentinan, schizophyllan, and pectin act as natural immunomodulators that suppress immune stress responses through biological mechanisms rather than chemical antagonism, avoiding the harmful side effects of conventional drugs

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the fundamental parameter of immune regulation from chemical suppression to biological modulation. By using polysaccharides with specific molecular structures and properties, the system achieves immune stress suppression through natural immunomodulation pathways, transforming the mechanism of action from pharmacological intervention to bioactive substance regulation

Inventive Principle:

Principle #35Parameter changes

2Reliability

If single plant polysaccharides are used for immune regulation, then some immune enhancement effect is achieved, but the efficacy is very limited under general application conditions

Engineering Contradiction:

Improveimmune regulation efficacyVSAvoidimmunity enhancement effect

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent merges multiple plant polysaccharide components into a composite preparation. By combining polysaccharides from different plant sources (such as lentinan from Lentinus edodes, schizophyllan from Schizophyllum commune, and pectin from citrus peels), the system achieves synergistic immune regulation effects that overcome the limitations of single polysaccharide preparations

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a composite polysaccharide material system with diverse molecular structures and biological activities. This composite preparation integrates multiple polysaccharide components with different immunomodulatory mechanisms, achieving enhanced and more reliable immune regulation efficacy compared to individual polysaccharide substances

Inventive Principle:

Principle #40Composite materials

3Reliability

If ovalbumin is used as an immunity-enhancing adjuvant, then immune function is improved, but immune stress response and allergic phenomena occur

Engineering Contradiction:

Improveimmune functionVSAvoidallergic reactions

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent converts the harmful allergic response to ovalbumin into a beneficial therapeutic opportunity. By using polysaccharide preparations to modulate the immune response, the system transforms the pathological immune stress reaction into a controlled immunomodulatory effect, where the same ovalbumin protein can be used therapeutically without triggering harmful allergic reactions

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent introduces polysaccharides as intermediary substances that mediate between ovalbumin and the immune system. These polysaccharides act as adjuvants that enhance the immunogenicity of ovalbumin while suppressing allergic responses, allowing ovalbumin to function as a beneficial immunity-enhancing agent without causing harmful side effects

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS20260069650A1Complex polysaccharide for regulating th1/th2 immune balance and preparation method and use thereof

Publication Date: 2026.03.12 INFINITUS (CHINA) CO LTD

AI summary

The present disclosure relates to a complex polysaccharide for regulating Th1/Th2 immune balance and a preparation method and use thereof. The complex polysaccharide is prepared from medicinal and edible homologous plants and edible fungi as raw materials. The raw materials include Agaricus Blazei Murill, seaweed, glycyrrhiza, polygonatum and honeysuckle; and compared with current drugs for treating ovalbumin-induced immune stress, the complex polysaccharide can be taken for a long time without obvious toxic or side effects. Moreover, the complex polysaccharide obtains a molecular weight segment effective to immunomodulation through co-extraction, and has obvious synergistic benefits compared to the immunomodulatory effect of the single polysaccharide. The complex polysaccharide can regulate the Th1/Th2 immune balance, prevent and/or inhibit the ovalbumin-induced immune stress response, providing effective support for the wide application of the ovalbumin.