Polysiloxane THC Transdermal Matrix for Sustained Skin Permeation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing transdermal delivery systems for cannabinoids face challenges due to their rapid metabolism and hydrophobic nature, leading to unstable concentration levels and poor skin penetration, limiting their effectiveness in maintaining consistent drug flux over extended periods.
Innovation Solution
A transdermal therapeutic system (TTS) comprising an active agent impermeable backing layer, an adhesive layer with at least 70% polysiloxane polymer, tetrahydrocannabinol, and a solubilizer, optionally with a protective layer, utilizing polysiloxane polymers that are amine-resistant and incorporating propylene glycol as a permeation enhancer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If cannabinoids are administered via conventional routes, then the active agent is rapidly metabolized and concentration levels decrease rapidly, but transdermal application is difficult due to high liphophilicity and strong tendency to bind to tissue and protein
Solution Approach 1:
The patent changes the physical and chemical parameters of the cannabinoid formulation by incorporating it into a transdermal matrix system with specific polymers and co-solvents, altering its solubility and penetration characteristics to enable transdermal delivery while maintaining stability
Solution Approach 2:
The patent uses composite material systems combining multiple polymers (polyisobutylene, acrylic adhesive, silicone adhesive) with cannabinoids and co-solvents to create a transdermal matrix that overcomes the limitations of single-material systems, enabling both transdermal penetration and sustained release
2Reliability
If active agents are applied via the skin using conventional TTS, then the active agent is released into the skin, but poor resorption occurs leading to limited commercial success
Solution Approach 1:
The patent optimizes the chemical composition parameters of the adhesive matrix, specifically the ratio of polyisobutylene to acrylic polymer and the selection of co-solvents, to enhance the solubility and resorption of cannabinoids while maintaining adhesive properties
Solution Approach 2:
The patent introduces co-solvents and permeation enhancers as intermediary substances that facilitate the transfer of cannabinoids from the adhesive matrix through the skin, improving resorption without compromising the integrity of the TTS system
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system provides a stable and continuous drug flux of tetrahydrocannabinol through the skin for up to 7 days, maintaining consistent concentration levels in the bloodstream.
Implementation Method 1
an adhesive layer comprising at least 70% by weight of at least one polysiloxane polymer, at least one tetrahydrocannabinol (THC) and at least one solubilizer
Implementation Method 2
wherein the transdermal therapeutic system further comprises propylene glycol as a permeation enhancer
Implementation Method 3
an adhesive layer comprising at least 70% by weight of at least one polysiloxane polymer
Data Source
Figure 1
Figure 2
AI summary
Disclosed is a transdermal therapeutic system comprising an active agent impermeable backing layer, at least one adhesive layer comprising at least 70% by weight of at least one polysiloxane polymer, at least one tetrahydrocannabinol (THC) and at least one solubilizer, and optionally a protective layer for removal before use, a method for its preparation and its use as a medicament.