Polysulfated Polysaccharides for Post-Operative Joint Pain
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Solution Overview
Problem
Current treatments for post-operative joint pain, particularly aseptic persistent pain after joint arthroplasty, are inadequate due to the negative effects of non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids on bone healing and cartilage metabolism, and the difficulty in diagnosing and managing this type of pain.
Innovation Solution
Administration of polysulfated polysaccharides, such as pentosan polysulfate (PPS), which reduces pain, improves joint function, and decreases bone marrow edema lesions without adverse events, offering an alternative to NSAIDs and corticosteroids.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If NSAIDs or corticosteroids are administered to treat post-operative joint pain, then pain relief is achieved, but bone healing and cartilage metabolism are negatively affected
Solution Approach 1:
The patent employs polysulfated polysaccharides as an intermediary substance that provides pain relief through a different mechanism than NSAIDs or corticosteroids. These compounds act as mediators by modulating inflammatory responses and protecting cartilage matrix, thereby achieving analgesia without the harmful side effects on bone healing and cartilage metabolism associated with conventional drugs.
2Object-affected harmful factors
If revision surgery is performed to treat aseptic persistent pain, then pain may be resolved, but the procedure is complicated and carries risks including potential worsening of pain
Solution Approach 1:
The patent applies polysulfated polysaccharides as a preliminary non-surgical treatment to address aseptic persistent pain before revision surgery is considered. This preliminary pharmacological intervention aims to reduce inflammation and protect cartilage, potentially resolving pain without the need for complicated surgery and its associated risks.
3Ease of operation
If standard non-surgical treatment with analgesics and anti-inflammatories is used, then pain management is provided, but adverse effects on bone and cartilage occur
Solution Approach 1:
The patent changes the chemical and pharmacological parameters of the treatment by using polysulfated polysaccharides instead of conventional NSAIDs or corticosteroids. These compounds have different molecular structures and mechanisms of action that provide pain management while avoiding the adverse effects on bone and cartilage metabolism, thus modifying the treatment parameters to achieve both efficacy and safety.
Data Source
AI summary
The present invention relates to medical use of polysulfated polysaccharides and compositions thereof in the treatment of post-operative joint pain in a mammal. In particular, the invention relates to the use of polysulfated polysaccharides and compositions thereof in the treatment of aseptic persistent pain after joint arthroplasty in a mammal.