Two-Component Polythiourethane Bone Repair with Controlled Curing
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Solution Overview
Problem
Current bone repair compositions using isocyanate reaction chemistry are sensitive to moisture, oxygen, temperature, and pH, affecting shelf-life stability, and have quick curing times that do not allow sufficient administration time, with mixing variations complicating the application process.
Innovation Solution
A two-component system comprising isocyanates and thiols forms a polythiourethane that includes a visual indicator for proper mixing, providing sufficient administration time before curing and improved shelf-life stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If polythiourethane compositions are used for bone repair, then the curing time is sufficiently long for administration, but the compositions are highly sensitive to moisture, oxygen, temperature, and pH affecting shelf-life stability
Solution Approach 1:
The invention divides the polythiourethane system into two separate components: a polyol component and a polyisocyanate component. Each component is packaged separately and only mixes when applied to the bone defect, eliminating shelf-life stability issues while maintaining controlled curing time for administration.
Solution Approach 2:
The invention modifies the reaction parameters by using specific catalysts (metal oxides like zinc oxide, lead oxide, or tin oxide) and controlling the ratio of hydroxyl to isocyanate groups to achieve a balanced curing time that is both sufficiently long for administration and stable during storage.
2Strength
If isocyanate reaction chemistry with polyols is used, then the compositions cure to a hard solid form, but the catalysts are sensitive to moisture, oxygen, temperature, and pH affecting shelf-life
Solution Approach 1:
The invention introduces metal oxide catalysts (zinc oxide, lead oxide, tin oxide) as intermediaries that mediate the reaction between polyol and polyisocyanate. These catalysts are less sensitive to environmental factors compared to traditional organic catalysts, maintaining shelf-life stability while still producing a hard solid cured form.
3Productivity
If polythiourethane compositions are used, then the curing time is quick, but there is insufficient time for user administration before curing
Solution Approach 1:
The invention prepares the bone defect site in advance by applying the polyol component first, then immediately applying the polyisocyanate component. This preliminary preparation allows the reaction to begin controlledly with sufficient administration time, while the quick curing still occurs after application to ensure proper setting.
4Ease of manufacture
If mixing instructions are provided for isocyanate and thiol reaction, then the compositions can be mixed, but user mixing techniques vary complicating the application process
Solution Approach 1:
The invention designs the mixing process to be self-regulating through the use of a polyol component with controlled viscosity and the polyisocyanate component that automatically mixes upon contact. The system self-regulates the mixing process without requiring precise user control, ensuring consistent results regardless of user technique variation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system offers a biocompatible and bioresorbable polythiourethane with a controlled curing time, ensuring effective application and stability, while reducing sensitivity to environmental factors.
Implementation Method 1
upon mixing (a) and (b), the functional thiol groups of the second component react with the functional isocyanate groups of the first component, thereby forming the polythiourethane
Implementation Method 2
the resulting polythiourethane cures into a solid form after the reaction is complete
Data Source
AI summary
Disclosed are compositions and kits useful for bone repair and reconstruction of bone defects such as bone voids and fractures. The compositions can include two reactive components that when mixed together form a polythiourethane that cures to a hard solid. Also disclosed are methods of making and using the compositions.