Crosslinked Polyurea Adhesive for Transdermal Patches
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Solution Overview
Problem
Existing adhesive compositions for transdermal drug delivery patches require multiple ingredients, increasing complexity and cost, and may have additives that decompose or leach, affecting their properties over time, while also causing skin residue and discomfort upon removal.
Innovation Solution
A crosslinked silyl-containing telechelic polyurea polymer with specific rheological properties, measured by G′ and G″ values, is developed, which functions as an excellent drug reservoir and adhesive without the need for additional additives, reducing ingredient complexity and minimizing skin residue.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If multiple ingredients including tackifiers are added to the adhesive composition, then adhesive properties and drug delivery performance are improved, but manufacturing complexity and cost increase
Solution Approach 1:
The patent extracts and eliminates the tackifier component from the adhesive composition while maintaining adhesive performance through a specifically designed polyurea polymer system with controlled molecular weight and structure. This removal of an ingredient simplifies the formulation and reduces complexity while preserving the required adhesive properties.
Solution Approach 2:
The polyurea polymer serves multiple functions simultaneously: it acts as the adhesive matrix, provides drug delivery capability, and eliminates the need for separate tackifiers. This multi-functionality reduces the total number of ingredients while maintaining or improving adhesive performance and drug delivery properties.
2Reliability
If multiple ingredients are added to enhance adhesive properties, then adhesive performance is improved, but the risk of decomposition and leaching increases
Solution Approach 1:
By removing tackifiers and other additives from the composition, the patent eliminates potential sources of decomposition and leaching. The simplified single-component polyurea system has fewer chemical interfaces and reactions that could lead to degradation over time, thereby improving composition stability.
Solution Approach 2:
The patent optimizes the molecular weight and structural parameters of the polyurea polymer to achieve the desired adhesive properties without requiring additional ingredients. By carefully controlling polymer synthesis parameters, the composition achieves both performance and stability with a simplified formulation.
3Strength
If traditional adhesive compositions are used, then adhesive strength is achieved, but skin residue and discomfort upon removal occur
Solution Approach 1:
The patent removes tackifiers and other residues from the adhesive composition, resulting in a cleaner removal profile. The polyurea polymer system is designed to bond strongly during use but removes cleanly without leaving skin residue or causing discomfort, eliminating the harmful effect while maintaining adhesive strength.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polymer composition provides effective transdermal drug delivery and adhesive properties, comparable to those with tackifying agents, while being simpler, more stable, and easier to manufacture, with improved skin compatibility and reduced residue.
Implementation Method 1
A pressure sensitive adhesive (PSA) is a material which forms a bond to a substrate when applied thereto with sufficient pressure
Implementation Method 2
patches, typically those designed for transdermal drug delivery
Implementation Method 3
capable of storing large amounts of drugs
Data Source
AI summary
The invention relates to an adhesive composition comprising a crosslinked silyl-containing telechelic polyurea polymer and methods for making the same. Typically, the composition is formed into a patch which shows excellent adhesion to the skin even when drugs and other additives are dissolved into the composition.