Poplar Bud Extract for Propolis Replacement in Therapeutic Compositions
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Solution Overview
Problem
There is a need for natural origin products that can replace bee-produced substances effectively, particularly due to the increasing interest in natural treatments and the dramatic extinction hazard faced by bees.
Innovation Solution
The use of poplar buds extracts as a composition for therapeutic purposes, which exhibit comparable or greater mucoadhesive properties and effective antibacterial activity compared to European propolis, without containing animal-derived or allergenic substances.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If bee-produced propolis is used for therapeutic purposes, then effective treatment of oropharyngeal and bacterial infections is achieved, but animal-derived substances and allergenic pollens are introduced into the treatment
Solution Approach 1:
The invention extracts and utilizes only the plant-derived resinous components (poplar buds extract) while excluding animal-derived substances (beeswax) and allergenic components (pollens) that are present in traditional propolis. This extraction principle allows maintaining therapeutic effectiveness while eliminating harmful factors.
Solution Approach 2:
The invention segments propolis into its constituent parts, identifying and isolating the beneficial plant resin components (poplar buds extract) from the harmful animal-derived and allergenic components. This segmentation enables selective use of therapeutic elements while discarding problematic substances.
2Object-affected harmful factors
If poplar buds extract is used as an alternative to propolis, then natural origin and absence of allergens is achieved, but mucoadhesive properties and antibacterial activity must be comparable or superior
Solution Approach 1:
The invention optimizes parameters of the poplar buds extract including concentration (0.1-70% w/w), extraction methods (hydro-alcoholic with 85° and 13° ethanol), and formulation conditions to achieve mucoadhesive properties and antibacterial activity comparable or superior to propolis, while maintaining the absence of harmful substances.
Solution Approach 2:
The invention creates composite formulations by combining poplar buds extract with pharmaceutically acceptable carriers, excipients, flavours, and preservatives to enhance mucoadhesive properties and antibacterial activity while maintaining the natural origin and absence of allergens.
3Adaptability or versatility
If natural origin products are developed to replace bee-produced substances, then sustainability and reduced allergenicity are achieved, but the product must maintain or exceed therapeutic effectiveness
Solution Approach 1:
The invention creates a plant-based copy (poplar buds extract) that replicates and potentially improves upon the therapeutic properties of bee-produced propolis. This copying approach uses poplar buds, the same plant source of resinous exudate that bees collect, to create a sustainable alternative with comparable or superior effectiveness.
Solution Approach 2:
The invention develops a universal natural product (poplar buds extract) that can serve multiple therapeutic functions including treatment of oropharyngeal cavity affections, urinary apparatus affections, digestive/excretory apparatus affections, skin affections, and bacterial infections, replacing the need for multiple different bee-produced substances.
Data Source
Figure 1A~1C
Figure 1D~2B
Figure 2C~3A
AI summary
The present invention relates to a composition comprising extract of poplar buds for use in the treatment of oropharyngeal cavity, urinary apparatus, digestive/excretory apparatus, skin affections and of bacterial infections.