Porcine Dermis Prosthesis for Parastomal Hernia Repair
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Solution Overview
Problem
Current synthetic prostheses used for treating parastomal hernias are unsuitable for septic surgery, cause patient discomfort, and have high relapse rates due to infection risks, necessitating a more effective and compatible biological alternative.
Innovation Solution
A biological prosthesis made from decellularized and deantigenized dermis from the tail area of pigs, cattle, or goats, with a thickness of 0.5 to 4 mm, processed to maintain mechanical strength and compatibility, and adapted for septic surgical conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If synthetic prostheses are used for treating parastomal hernias, then the structural support and durability are improved, but the risk of infection and complications increases in septic surgery conditions
Solution Approach 1:
The patent changes the material parameter from synthetic to biological (porcine dermis), which fundamentally alters the interaction with septic environments. Biological tissue has different biochemical properties that reduce infection risk while maintaining mechanical strength, directly resolving the contradiction between durability and infection susceptibility in septic surgery
Solution Approach 2:
The prosthesis uses a composite structure combining porcine dermis with specific architectural design (mesh configuration, pore structure) to achieve both biological compatibility in septic conditions and adequate mechanical support. The composite nature allows simultaneous optimization of biological and mechanical properties
2Duration of action of stationary object
If synthetic prostheses are used for treating parastomal hernias, then the durability is improved, but the patient comfort and pain levels worsen
Solution Approach 1:
Changing from synthetic to biological material fundamentally alters the patient's physiological response. Biological dermis integrates with surrounding tissue without causing the chronic inflammation and pain associated with synthetic materials, while maintaining long-term durability through biological incorporation
3Object-affected harmful factors
If animal dermis is used for producing prostheses in parastomal hernia cases, then the biological compatibility is improved, but the manufacturing complexity increases due to required manipulations and assemblies
Solution Approach 1:
The patent merges multiple dermis pieces into a single integrated prosthesis unit with standardized configuration. This consolidation reduces the number of separate manipulations and assemblies required during both manufacturing and surgical implantation, while maintaining the biological compatibility benefits of animal dermis
4Strength
If synthetic prostheses are used for treating parastomal hernias, then the initial structural integrity is improved, but the relapse rate increases due to infection complications
Solution Approach 1:
Changing to biological material parameter fundamentally improves reliability in septic conditions. The biological dermis resists infection better than synthetic materials, preventing the chain of complications that lead to relapse, while maintaining sufficient structural integrity through its mechanical properties and architectural design
Data Source
AI summary
The subject of the invention is a biological prosthesis suitable for gastrointestinal surgery and in particular for the treatment of parastomal hernias. It has a thickness (12) of between 0.5 and 4 mm, consisting of dermis removed from a part of an animal belonging to the family of pigs, cattle or goats, with the said part of the animal corresponding to a part extending from the area (16) located at the base of the tail next to the junction of the last sacral vertebrae up to an area (18) starting at the base of the tail and encompassing the circumference of at least a part of the caudal vertebrae.