Water-Soluble Porous Carrier Particles for Complete Drug Release
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Solution Overview
Problem
Porous materials made from inorganic compounds have high specific surface areas but are water-insoluble, leading to incomplete release of functional ingredients when administered in the body.
Innovation Solution
Development of water-soluble porous carrier particles with a helical structure incorporating glucose units, achieving a high BET specific surface area of 1 m^2/g or greater, which are capable of carrying functional ingredients and completely dissolving in vivo.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Area of stationary object
If a porous inorganic material is used as a carrier, then the specific surface area is increased, but the water solubility is poor leading to incomplete release of functional ingredients
Solution Approach 1:
The invention uses a composite structure consisting of an inorganic porous core (providing high specific surface area) covered with an amorphous silica layer (providing water solubility). This composite material combines the advantages of both inorganic porous materials and water-soluble materials, allowing the carrier to maintain high surface area while becoming water-soluble for complete release of functional ingredients in the body.
2Stability of the object's composition
If an inorganic compound is used as a carrier, then the structural stability is improved, but the dissolution in body fluids is prevented
Solution Approach 1:
The invention applies different properties to different parts of the carrier: the inner core maintains inorganic porous structure for structural stability, while the outer surface is modified with an amorphous silica layer that provides water solubility. This local differentiation allows the carrier to simultaneously achieve structural integrity and dissolution capability in body fluids.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The water-soluble porous carrier particles effectively increase the carrying capacity of functional ingredients and ensure complete release and dissolution within the body, enhancing the administration of active pharmaceutical ingredients.
Implementation Method 1
a water-soluble polymer that has a helical structure including glucose as a unit, in which the porous carrier particles have a BET specific surface area of 1 m2/g or more
Implementation Method 2
The water-soluble porous carrier particles effectively increase the carrying capacity of functional ingredients and ensure complete release and dissolution within the body
Data Source
Figure 1~2
AI summary
Porous carrier particles include a water-soluble polymer that has a helical structure using glucose as a unit, in which the porous carrier particles have a BET specific surface area of 1 m2/g or greater. It is preferable that the water-soluble polymer is a water-soluble polysaccharide. It is preferable that the water-soluble polysaccharide is one or more selected from the group consisting of dextrin, dextran, agarose, and pullulan.